| Direct visualization of deep brain stimulation targets in Parkinson disease with the use of 7-tesla magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 20380532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECT: A challenge associated with deep brain stimulation (DBS) in treating advanced Parkinson disease (PD) is the direct visualization of brain nuclei, which often involves indirect approximations of stereotactic targets. In the present study, the authors compared T2*-weighted images obtained using 7-T MR imaging with those obtained using 1.5- and 3-T MR imaging to ascertain whether 7-T imaging enables better visualization of targets for DBS in PD. METHODS: The authors compared 1.5-, 3-, and 7-T MR images obtained in 11 healthy volunteers and 1 patient with PD. RESULTS: With 7-T imaging, distinct images of the brain were obtained, including the subthalamic nucleus (STN) and internal globus pallidus (GPi). Compared with the 1.5- and 3-T MR images of the STN and GPi, the 7-T MR images showed marked improvements in spatial resolution, tissue contrast, and signal-to-noise ratio. CONCLUSIONS: Data in this study reveal the superiority of 7-T MR imaging for visualizing structures targeted for DBS in the management of PD. This finding suggests that by enabling the direct visualization of neural structures of interest, 7-T MR imaging could be a valuable aid in neurosurgical procedures. |
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Authors:
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Zang-Hee Cho; Hoon-Ki Min; Se-Hong Oh; Jae-Yong Han; Chan-Woong Park; Je-Geun Chi; Young-Bo Kim; Sun Ha Paek; Andres M Lozano; Kendall H Lee |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurosurgery Volume: 113 ISSN: 1933-0693 ISO Abbreviation: J. Neurosurg. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-09-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
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Languages: eng Pagination: 639-47 Citation Subset: AIM; IM |
Affiliation:
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Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Republic of Korea. zcho@gachon.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / pathology Deep Brain Stimulation / methods* Feasibility Studies Globus Pallidus / pathology Humans Magnetic Resonance Imaging* / instrumentation, methods Middle Aged Parkinson Disease / pathology*, therapy* Phantoms, Imaging Subthalamic Nucleus / pathology Therapy, Computer-Assisted / instrumentation, methods* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K08 NS 52232/NS/NINDS NIH HHS; K08 NS052232-03/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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