Document Detail


Direct vascular actions of methyclothiazide in remodeled mesenteric arteries from hypertensive patients.
MedLine Citation:
PMID:  11710791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vitro experiments were designed to assess the inhibitory effect of the thiazide diuretic methyclothiazide (MCTZ) on contractile responses to norepinephrine (NE) of mesenteric rings from hypertensive patients and normotensive controls. Arteries were taken from portions of mesocolon from 24 patients: 13 hypertensives and 11 normotensives. Changes in the tension of mesenteric ring preparations were measured isometrically. Histologic studies showed that the arteries from hypertensive patients exhibited 1) a greater media thickness-to-lumen diameter ratio, 2) a smaller lumen diameter, and 3) identical media cross-sectional area as those of normotensive controls. At the physiologic level, the hypertensive and normotensive arteries display similar contractile responses to KCl and NE. Furthermore, our results indicate that MCTZ induces concentration-dependent inhibition of the vasoconstrictor responses to NE. This study provides evidence that hypertension is associated with the remodeling of the human mesenteric artery and that MCTZ is as efficient in inhibiting the contractile response induced by NE on hypertensive than on normotensive arteries.
Authors:
B Colas; T Collin; F Safraou; D Chatelain; C Cordonnier; X Henry; M Safar; M Andrejak; M Slama
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  14     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-16     Completed Date:  2002-02-15     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  989-94     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie et Physiopathologie Cardiovasculaire, Faculté de Médecine, Amiens, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Diuretics
Female
Humans
Hypertension / physiopathology*
Male
Mesenteric Arteries / drug effects*
Methyclothiazide / pharmacology*
Middle Aged
Norepinephrine / antagonists & inhibitors*
Sodium Chloride Symporter Inhibitors / pharmacology*
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Diuretics; 0/Sodium Chloride Symporter Inhibitors; 135-07-9/Methyclothiazide; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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