Document Detail


Direct toxic effect of iodide in excess on iodine-deficient thyroid glands: epithelial necrosis and inflammation associated with lipofuscin accumulation.
MedLine Citation:
PMID:  3720915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Involution of thyroid hyperplasia (induced by a low iodine diet and a goitrogen, propylthiouracil, PTU) was obtained in mice by administering a high or a moderate dose of iodide (HID or MID, respectively). In HID involuting glands, vasoconstriction was observed after 12 hr whereas necrosis and inflammation were very abundant as early as after 6 hr and maximal after 48 hr. They were not prevented by papaverine by which vasoconstriction was inhibited, but were inhibited by the continuation of PTU by which iodide oxidation and organification were inhibited. Lipofuscin inclusions in thyroid and inflammatory cells were always associated with necrosis. On the contrary, when involution was induced by MID or by HID + triiodothyronine (T3), or by T3 alone, neither necrosis nor inflammation occurred and apoptosis was the only mode of cell deletion. No lipofuscin inclusion occurred. Our results demonstrate that iodide in excess, after being oxidized or organified, is directly toxic for iodine-deficient thyroid cells. The presence of lipofuscin suggests that its toxicity is mediated by lipid peroxidation, a consequence of production of free radicals in excess.
Authors:
I Mahmoud; I Colin; M C Many; J F Denef
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental and molecular pathology     Volume:  44     ISSN:  0014-4800     ISO Abbreviation:  Exp. Mol. Pathol.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-31     Completed Date:  1986-07-31     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370711     Medline TA:  Exp Mol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Epithelium / pathology
Humans
Iodides / pharmacology*
Iodine / deficiency*
Lipofuscin / metabolism*
Male
Mice
Mice, Inbred ICR
Microscopy, Electron
Necrosis
Papaverine / pharmacology
Pigments, Biological / metabolism*
Thyroid Gland / drug effects*,  pathology,  ultrastructure
Thyroiditis / pathology
Chemical
Reg. No./Substance:
0/Iodides; 0/Lipofuscin; 0/Pigments, Biological; 58-74-2/Papaverine; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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