Document Detail


Direct screening of solution phase combinatorial libraries encoded with externally sensitized photolabile tags.
MedLine Citation:
PMID:  16956977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Solution phase combinatorial chemistry holds an enormous promise for modern drug discovery. Much needed are direct methods to assay such libraries for binding of biological targets. An approach to encoding and screening of solution phase libraries has been developed based on the conditional photorelease of externally sensitized photolabile tags. The encoding tags are released into solution only when a sought-for binding event occurs between the ligand and the receptor, outfitted with an electron-transfer sensitizer. The released tags are analyzed in solution revealing the identity of the lead ligand or narrowing the range of potential leads.
Authors:
Rudresha Kottani; Roman A Valiulin; Andrei G Kutateladze
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-09-06
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  103     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-20     Completed Date:  2006-12-14     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13917-21     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208-2436, USA.
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MeSH Terms
Descriptor/Qualifier:
Avidin / chemistry,  metabolism
Biotin / chemistry,  metabolism
Combinatorial Chemistry Techniques*
Drug Design
Libraries*
Molecular Structure
Photochemistry*
Solutions / chemistry
Grant Support
ID/Acronym/Agency:
GM067655/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Solutions; 1405-69-2/Avidin; 58-85-5/Biotin
Comments/Corrections

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