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Direct ortho-Arylation of ortho-Substituted Benzoic Acids: Overriding Pd-Catalyzed Protodecarboxylation.
MedLine Citation:
PMID:  23373630     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ortho-Arylation of ortho-substituted benzoic acids is a challenging process due to the tendency of the reaction products toward Pd-catalyzed protodecarboxylation. A simple method for preventing decarboxylation in sterically hindered benzoic acids is reported. The method described represents a reliable and broadly applicable entry to 2-aryl-6-substituted benzoic acids.
Authors:
Carlos Arroniz; Alan Ironmonger; Gerry Rassias; Igor Larrosa
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-1
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Queen Mary University of London , School of Biological and Chemical Sciences, Joseph Priestley Building, Mile End Road, London E1 4NS, United Kingdom, and GlaxoSmithKline Medicines Research Centre , Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.
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