Document Detail


Direct numerical simulation of transitional flow in a stenosed carotid bifurcation.
MedLine Citation:
PMID:  18656199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The blood flow dynamics of a stenosed, subject-specific, carotid bifurcation were numerically simulated using the spectral element method. Pulsatile inlet conditions were based on in vivo color Doppler ultrasound measurements of blood velocity. The results demonstrated the transitional or weakly turbulent state of the blood flow, which featured rapid velocity and pressure fluctuations in the post-stenotic region of the internal carotid artery (ICA) during systole and laminar flow during diastole. High-frequency vortex shedding was greatest downstream of the stenosis during the deceleration phase of systole. Velocity fluctuations had a frequency within the audible range of 100-300Hz. Instantaneous wall shear stress (WSS) within the stenosis was relatively high during systole ( approximately 25-45Pa) compared to that in a healthy carotid. In addition, high spatial gradients of WSS were present due to flow separation on the inner wall. Oscillatory flow reversal and low pressure were observed distal to the stenosis in the ICA. This study predicts the complex flow field, the turbulence levels and the distribution of the biomechanical stresses present in vivo within a stenosed carotid artery.
Authors:
Seung E Lee; Sang-Wook Lee; Paul F Fischer; Hisham S Bassiouny; Francis Loth
Related Documents :
24938399 - 3-nitropropionic acid-induced ischemia tolerance in the rat brain is mediated by reduce...
4850939 - Cerebral blood flow, internal carotid artery pressure, and the eeg as a guide to the sa...
431429 - Oculoplethysmography and carotid phonoangiography for the noninvasive detection of extr...
2279569 - Transcranial doppler sonography and somatosensory evoked potential monitoring in caroti...
14580159 - Impairment of blood-brain barrier integrity during carotid surgery as assessed by serum...
17936799 - Can carotid body perfusion act as a respiratory controller?
11457429 - Induced mitochondrial failure in the feline brain: implications for understanding acute...
25440389 - Modern banking, collection, compatibility testing and storage of blood and blood compon...
11297159 - Diastolic forward blood flow in the pulmonary arteries of normal children: a doppler ec...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-07-24
Journal Detail:
Title:  Journal of biomechanics     Volume:  41     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-10-03     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2551-61     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity / physiology
Carotid Stenosis / physiopathology*
Computer Simulation*
Grant Support
ID/Acronym/Agency:
2R01HL55296-04A2/HL/NHLBI NIH HHS; R01 HL055296-04A2/HL/NHLBI NIH HHS; R01 HL055296-05/HL/NHLBI NIH HHS; R01 HL055296-06/HL/NHLBI NIH HHS; R01 HL055296-07/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europe...
Next Document:  Mechanical mechanisms of thrombosis in intact bent microvessels of rat mesentery.