| Direct noninvasive quantification of lactate and high energy phosphates simultaneously in exercising human skeletal muscle by localized magnetic resonance spectroscopy. | |
| | |
MedLine Citation:
|
PMID: 17390348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A novel method based on interleaved localized 31P- and 1H MRS is presented, by which lactate accumulation and the accompanying changes in high energy phosphates in human skeletal muscle can be monitored simultaneously during exercise and recovery. Lactate is quantified using a localized double quantum filter suppressing the abundant lipid signals while taking into account orientation dependent signal modulations. Lactate concentration after ischemic exercise directly quantified by DQF 1H spectroscopy was 24 +/- 3 mmol/L cell water, while 22 +/- 3 mmol/L was expected on the basis of 31P MRS acquired simultaneously. Lactate concentration in a sample of porcine meat was estimated to be 40 +/- 7 mmol/L by means of DQF quantitation, versus 39 +/- 5 mmol/L by biochemical methods. Excellent agreement is shown between lactate concentrations measured noninvasively by 1H MRS, measured biochemically ex vivo, and inferred indirectly in vivo from changes in pH, P(i), and PCr as obtained from 31P MRS data. |
| | |
Authors:
|
Martin Meyerspeer; Graham J Kemp; Vladimir Mlynárik; Martin Krssák; Julia Szendroedi; Peter Nowotny; Michael Roden; Ewald Moser |
Related Documents
:
|
6913478 - Relevance of muscle fibre type to fatigue in short intense and prolonged exercise in man. 3834108 - The effects of prior exercise on the lactate and ventilatory thresholds. 17876968 - A quantitative analysis and qualitative explanation of the individual differences in af... 22606868 - Common mental disorders among civil aviation pilots. 8911828 - Effects of moderate endurance exercise and training on in vitro lymphocyte proliferatio... 12070228 - Invited review: effect of acute exercise on insulin signaling and action in humans. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 57 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-04-02 Completed Date: 2007-05-24 Revised Date: 2007-06-19 |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
|
Languages: eng Pagination: 654-60 Citation Subset: IM |
Affiliation:
|
MR Centre of Excellence, Medical University of Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Water / metabolism Humans Hydrogen-Ion Concentration Lactates / metabolism* Leg Magnetic Resonance Spectroscopy / methods* Muscle Contraction* Muscle, Skeletal / metabolism* Phantoms, Imaging Phosphates / metabolism* Swine |
| Chemical | |
Reg. No./Substance:
|
0/Lactates; 0/Phosphates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gradient-echo and CRAZED imaging for minute detection of Alzheimer plaques in an APPV717I x ADAM10-d...
Next Document: Rapid quantitation of cardiovascular flow using slice-selective fourier velocity encoding with spira...