Document Detail

Direct migration inhibition test with leukocytes as indicator of mycobacterial antigens in the human body.
MedLine Citation:
PMID:  109977     Owner:  NLM     Status:  MEDLINE    
In 32 patients with newly detected pulmonary tuberculosis positive on smear and culture, included in a controlled clinical trial, a significant correlation between diminishing inhibition of leukocyte migration (induced by PPD) and reduction of mycobacterial population in the sputum during the course of chemotherapy has been demonstrated. The changes of mycobacterial population in the host have been assessed in two ways: an indirect assessment was made from the time taken to achieve sputum smear and culture negativity; a direct assessment was based on repeated quantitative determinations of tubercle bacilli in the sputum. The direct migration inhibition test with peripheral buff-coated leukocytes, is an easy and reliable correlate of delayed hypersensitivity to mycobacterial antigens in the human body. It is suggested that its use in individual patients could indicate changes in mycobacterial population, particularly after microbiological negativity has been obtained, and thus could be helpful in estimating the optimum duration of chemotherapy.
L Trnka; J Skvor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tubercle     Volume:  60     ISSN:  0041-3879     ISO Abbreviation:  Tubercle     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-08-16     Completed Date:  1979-08-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1273730     Medline TA:  Tubercle     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
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MeSH Terms
Antigens, Bacterial / analysis*
Cell Migration Inhibition
Leukocytes / immunology*
Mycobacterium tuberculosis / immunology*,  isolation & purification
Sputum / microbiology
Tuberculosis, Pulmonary / drug therapy,  immunology*
Reg. No./Substance:
0/Antigens, Bacterial

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