Document Detail

Direct measurement of nipradilol-derived nitric oxide in the vascular wall of canine femoral arteries.
MedLine Citation:
PMID:  16025369     Owner:  NLM     Status:  MEDLINE    
Nipradilol (NP: 3,4-dihydro-8-[2-hydroxy-3-isopropylamino]propoxy-3-nitroxy-2H-1-benzopyran) shows not only beta-adrenoreceptor-blocking effects but also nitroglycerin-like vasodilatory action. We aimed to directly measure NP-derived nitric oxide (NO) in the vascular wall. An NO-sensitive microelectrode was inserted into the vascular media (the vasodilatory action site of NO) of isolated perfused canine femoral arteries. Each vessel was perfused with 15 microM NP in the presence or absence of 1 mM N-ethylmaleimide (NEM; a thiol alkylator). Intravascular-wall NO concentration increased 181+/-34 nM during NP perfusion (P<0.001 vs basal, n=10) with an average base-to-peak reaction time of 1.5+/-0.1 min (P<0.0001, n=8). Concomitant perfusion of NEM with NP attenuated the intravascular-wall NO production significantly (P<0.0001 vs NP only). It is concluded that NP is metabolized to NO in the vascular wall of an isolated canine femoral artery in large part through a metabolic process involving thiols with a base-to-peak reaction time of about 1.5 min.
Seiichi Mochizuki; Yoko Chiba; Osamu Hiramatsu; Hiroyuki Tachibana; Hiroshi Nakamoto; Eiji Toyota; Yasuo Ogasawara; Fumihiko Kajiya
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart and vessels     Volume:  20     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2006-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
Department of Medical Engineering, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Femoral Artery / metabolism*
Nitric Oxide / metabolism*
Propanolamines / pharmacology*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 81486-22-8/K 351

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