Document Detail


Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1).
MedLine Citation:
PMID:  15811326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By using the C-terminal 112-residue of band 3 to screen the K562 cDNA library, we find that the p16 interacts with band 3, which was confirmed both in yeast and in mammalian cells. Functional experiments show that p16 facilitates the movement of band 3 to plasma membrane with increased anion transport activity in 293t cells. Moreover, expression of endogenous p16 in 293t cells was increased at 24 and 36 h after transfection with band 3. Our findings provide a novel regulation pathway for both band 3 and p16.
Authors:
Guo-Hui Fu; Yong Wang; Yu-Hui Xi; Wei-Wei Shen; Xiao-Yan Pan; Wu-Zhong Shen; Xiao-Shu Jiang; Guo-Qiang Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  579     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-06     Completed Date:  2005-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2105-10     Citation Subset:  IM    
Affiliation:
Department of Pathophysiology, Shanghai Institute of Hematology, Rui-Jin Hospital, Shanghai Second Medical University (SSMU), Shanghai 200025, PR China. guohuifu@shsmu.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Anion Exchange Protein 1, Erythrocyte / metabolism*
Blotting, Western
Cell Line
Cyclin-Dependent Kinase Inhibitor p16 / metabolism*
Humans
Immunohistochemistry
Immunoprecipitation
Molecular Sequence Data
Protein Binding
Two-Hybrid System Techniques
Chemical
Reg. No./Substance:
0/Anion Exchange Protein 1, Erythrocyte; 0/Cyclin-Dependent Kinase Inhibitor p16

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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