| Direct inhibitory effect of erythromycin on the gallbladder muscle. | |
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MedLine Citation:
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PMID: 9834366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Erythromycin, a macrolide antibiotic, stimulates motor activity in various parts of the gastrointestinal tract in humans and animals. This effect of erythromycin resembles that of motilin, a gastrointestinal hormone, in evoking contractions similar to phase 3 activity of the migrating motor complex. Motilin induces contractions in the canine gallbladder but fails to evoke any response, either in vivo or in vitro, in the human gallbladder. Surprisingly, erythromycin stimulates human gallbladder emptying in healthy volunteers and in persons with diabetic autonomic neuropathy. In the present study we examined the effect of erythromycin on chemically and electrically evoked contractions of isolated gallbladders from guinea pigs and humans by use of isometric force measurements. Carbachol, a muscarinic cholinergic agonist, evoked gallbladder contractions that were diminished by erythromycin in a concentration-dependent manner: at 200 micromol/L the contractions were 86% +/- 20% of the control response, at 500 micromol/L they were 63% +/- 21% of control, and at 1000 micromol/L they were 41% +/- 20% of control (P <0.05, N = 10, mean +/- standard deviation). Electrically evoked gallbladder contractions were reduced to 68% +/- 18% of the control response with the addition of 500 micromol/L of erythromycin and to 56% +/- 19% of control after the addition of 1000 micromol/L (P <0.05, N = 8). Guinea pig but not human gallbladders contracted after stimulation with the alpha-adrenergic agonist phenylephrine. Erythromycin reduced these contractions in a concentration-dependent manner but had no effect on gallbladder contractions induced by bradykinin. In human gallbladder strips, erythromycin at 500 micromol/L reduced the contractile response to electrical stimulation to 71% +/- 16% of the control value (N = 10 [5 patients], P <0.01) and the carbachol-evoked contractions to 53% +/- 24% (P <0.01, N = 32). The inhibitory effect of erythromycin persisted in the presence of the nerve blocker tetrodotoxin at 1 micromol/L. It is concluded that erythromycin has a direct inhibitory effect on guinea pig and human gallbladder contractions. |
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Authors:
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A Nissan; Y Mashriki; J M Zhang; Y Haskel; H R Freund; M Hanani |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Volume: 1 ISSN: 1091-255X ISO Abbreviation: J. Gastrointest. Surg. Publication Date: 1997 Jul-Aug |
Date Detail:
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Created Date: 2006-10-19 Completed Date: 2006-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706084 Medline TA: J Gastrointest Surg Country: United States |
Other Details:
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Languages: eng Pagination: 331-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, Hadassah University Hospital Mount Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Animals Anti-Bacterial Agents / pharmacology* Benzyl Alcohol / pharmacology Bradykinin / pharmacology Carbachol / pharmacology Dose-Response Relationship, Drug Electric Stimulation Erythromycin / pharmacology* Gallbladder / drug effects* Gallbladder Emptying / drug effects Gastrointestinal Agents / pharmacology* Guinea Pigs Male Muscarinic Agonists / pharmacology Muscle Contraction / drug effects* Muscle, Smooth / drug effects Phenylephrine / pharmacology Tetrodotoxin / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Anti-Bacterial Agents; 0/Gastrointestinal Agents; 0/Muscarinic Agonists; 0/Vasodilator Agents; 100-51-6/Benzyl Alcohol; 114-07-8/Erythromycin; 4368-28-9/Tetrodotoxin; 51-83-2/Carbachol; 58-82-2/Bradykinin; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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