| Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease. | |
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MedLine Citation:
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PMID: 19715410 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Despite the last three decades of progress in improving cardiovascular outcomes via renin-angiotensin-aldosterone system (RAAS) blockade in hypertensive patients, substantial residual morbidity/mortality remains. Attempts to improve clinical outcomes by combining angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have yielded mixed results. Adverse effects of RAAS blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may relate to compensatory increases in plasma renin activity (PRA). The first-in-class direct renin inhibitor, aliskiren, blocks the RAAS at its point-of-activation, suppressing PRA and attenuating increases associated with other antihypertensives. Aliskiren (with or without other agents) provides significant and prolonged blood pressure reductions in a broad range of hypertensive patients and is well tolerated. Initial results from organ-protection studies are promising. Long-term outcomes studies should yield valuable information regarding the significance of direct renin inhibition in clinical practice. |
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Authors:
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C Venkata S Ram |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Future cardiology Volume: 5 ISSN: 1744-8298 ISO Abbreviation: Future Cardiol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101239345 Medline TA: Future Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 453-65 Citation Subset: IM |
Affiliation:
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Texas Blood Pressure Institute, Dallas Nephrology Associates, University of Texas Southwestern, Medical Center, 1420 Viceroy Drive, Dallas, TX 75235, USA. ramv@dneph.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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