Document Detail


Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease.
MedLine Citation:
PMID:  19715410     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Despite the last three decades of progress in improving cardiovascular outcomes via renin-angiotensin-aldosterone system (RAAS) blockade in hypertensive patients, substantial residual morbidity/mortality remains. Attempts to improve clinical outcomes by combining angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have yielded mixed results. Adverse effects of RAAS blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may relate to compensatory increases in plasma renin activity (PRA). The first-in-class direct renin inhibitor, aliskiren, blocks the RAAS at its point-of-activation, suppressing PRA and attenuating increases associated with other antihypertensives. Aliskiren (with or without other agents) provides significant and prolonged blood pressure reductions in a broad range of hypertensive patients and is well tolerated. Initial results from organ-protection studies are promising. Long-term outcomes studies should yield valuable information regarding the significance of direct renin inhibition in clinical practice.
Authors:
C Venkata S Ram
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Future cardiology     Volume:  5     ISSN:  1744-8298     ISO Abbreviation:  Future Cardiol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239345     Medline TA:  Future Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-65     Citation Subset:  IM    
Affiliation:
Texas Blood Pressure Institute, Dallas Nephrology Associates, University of Texas Southwestern, Medical Center, 1420 Viceroy Drive, Dallas, TX 75235, USA. ramv@dneph.com
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