| Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart. | |
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MedLine Citation:
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PMID: 18784369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Nodal signaling pathway plays a conserved role in determining left-sided identity in vertebrates with this early left-right (L/R) patterning influencing the asymmetric development and placement of visceral organs. We have studied the role of Nodal signaling in asymmetric cardiac morphogenesis in zebrafish and describe two distinct rotations occurring within the heart. The first is driven by an asymmetric migration of myocardial cells during cardiac jogging, resulting in the conversion of the L/R axis to the dorsal-ventral (D/V) axis of the linear heart. This first rotation is directly influenced by the laterality of asymmetric gene expression. The second rotation occurs before cardiac looping and positions the original left cells exposed to Nodal signaling back to the left of the wild-type (WT) heart by 48 hours postfertilization (hpf). The direction of this second rotation is determined by the laterality of cardiac jogging and is not directly influenced by asymmetric gene expression. Finally, we have identified a role for Nodal signaling in biasing the location of the inner ventricular and outer atrial curvature formations. These results suggest that Nodal signaling directs asymmetric cardiac morphogenesis through establishing and subsequently reinforcing laterality information over the course of cardiac development. |
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Authors:
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Kari Baker; Nathalia G Holtzman; Rebecca D Burdine |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-09-10 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 105 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-17 Completed Date: 2008-10-09 Revised Date: 2013-03-15 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 13924-9 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology, Princeton University, Washington Road MOF433, Princeton, NJ 08550, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning* Cell Movement Gene Expression Regulation, Developmental Heart / embryology* Left-Right Determination Factors Myocardium / cytology, metabolism* Nodal Protein Signal Transduction* Transforming Growth Factor beta / genetics, metabolism* Zebrafish / embryology*, genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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1R01HD048584/HD/NICHD NIH HHS; R01 HD048584/HD/NICHD NIH HHS; R01 HD048584-02/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Left-Right Determination Factors; 0/Nodal Protein; 0/Transforming Growth Factor beta |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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