| Direct and indirect roles of the LTbetaR pathway in central tolerance induction. | |
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MedLine Citation:
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PMID: 20675191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medullary thymic epithelial cells (mTECs) play a critical role in thymic negative selection of autoreactive thymocytes, especially for thymocytes specific for peripheral tissue-restricted self-antigens (TRA). Deficiency in lymphotoxin b receptor (LTbetaR) is associated with peripheral tissue inflammation, but whether this is caused by defective negative selection has been unclear; the significance of the LTbetaR pathway for negative selection is evident in some models but not others. Here, we revisit the data and clarify the role of LTbetaR in mTEC development and function and thymic TRA expression. These processes are discussed as potential mechanisms for LTbetaR-mediated control of negative selection. |
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Authors:
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Mingzhao Zhu; Nicholas K Brown; Yang-Xin Fu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-02 |
Journal Detail:
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Title: Trends in immunology Volume: 31 ISSN: 1471-4981 ISO Abbreviation: Trends Immunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2010-10-01 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. zhumz@ibp.ac.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Epithelial Cells / cytology, immunology, metabolism Humans Immune Tolerance* Lymphotoxin beta Receptor / immunology*, metabolism Signal Transduction* Thymus Gland / cytology, immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI062026-08/AI/NIAID NIH HHS; R01 AI062026-09/AI/NIAID NIH HHS; R01 CA134563-02/CA/NCI NIH HHS; R01 DK058897-08/DK/NIDDK NIH HHS; R01 DK058897-09/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lymphotoxin beta Receptor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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