Document Detail

Direct and indirect lactate oxidation in trained and untrained men.
MedLine Citation:
PMID:  23788576     Owner:  NLM     Status:  Publisher    
Lactate has been shown to be an important oxidative fuel. We aimed to quantify total lactate oxidation rate (Rox) and its direct versus indirect (glucose that is gluconeogenically derived from lactate and subsequently oxidized) components (mg⋅kg(-1)⋅min(-1)) during rest and exercise in humans. We also investigated the effects of endurance training, exercise intensity, and blood lactate concentration ([lactate]b) on direct and indirect lactate oxidation. Six untrained (UT) and six trained (T) men completed 60 min of constant load exercise at power outputs (PO) corresponding to their lactate threshold (LT). Trained subjects completed two additional 60-min sessions of constant load exercise at 10% below the LT workload (LT-10%), one of which included a lactate clamp (LT-10%+LC). Rox was higher at LT in T (22.7 ± 2.9, 75% VO2peak) compared to UT (13.4 ± 2.5, 68% VO2peak, P < 0.05). Increasing [lactate]b (LT-10%+LC, 67% VO2peak) significantly increased lactate Rox (27.9 ± 3.0) compared to its corresponding LT-10% control (15.9 ± 2.2, P < 0.05). Direct and indirect lactate oxidation rates increased significantly from rest to exercise and their relative partitioning remained relatively constant in all trials, but differed between T and UT: direct oxidation comprised 75% of total lactate oxidation in UT and 90% in T suggesting the presence of training-induced adaptations. Partitioning of total carbohydrate (CHO) utilization showed that subjects derived one-third of CHO energy from blood lactate, and exogenous lactate infusion significantly increased lactate oxidation, causing a glycogen sparing effect in exercising muscle.
Chi-An W Emhoff; Laurent André Messonnier; Michael A Horning; Jill A Fattor; Thomas J Carlson; George A Brooks
Related Documents :
21361796 - Lessons learned from north carolina public health regional surveillance teams' regional...
2588686 - Effect of intracerebrally injected aminophylline, vinpocetinum, vasoactive intestinal p...
11079516 - Expiratory flow limitation confounds ventilatory response during exercise in athletes.
11316646 - Fog-induced respiratory responses are attenuated by nedocromil sodium in humans.
21609916 - Clinical benefits to vestibular rehabilitation in multiple sclerosis. report of 4 cases.
8408166 - Temperature changes during exercise stress testing in children with burns.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-20
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1University of California Berkeley.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Contribution of nitric oxide in the contraction-induced rapid vasodilation in young and older adults...
Next Document:  Impaired postprandial fullness in type 2 diabetic subjects is rescued by acute exercise independentl...