Document Detail

Direct in vivo effects of nitric oxide on the coronary circulation.
MedLine Citation:
PMID:  8897955     Owner:  NLM     Status:  MEDLINE    
To determine the direct in vivo effects of nitric oxide (NO) on the coronary circulation, we infused NO-saturated saline (1.0 +/- 0.1 mmol/l) into the coronary arteries of anesthetized dogs and measured changes in coronary blood flow velocity (CBFV) with a Doppler catheter, changes in coronary artery size with quantitative angiography, and transmural myocardial perfusion with radioactive microspheres. Boluses of NO (1-8 micromol) caused a stepwise increase in CBFV (3.1 +/- 0.3 x basal CBFV at 8 micromol) similar to that caused by adenosine (2.6 +/- 0.3 x basal CBFV, maximal dose). Continuous subselective infusions (0.1, 1.0, and 4.0 micromol/min) caused dose-dependent increases in CBFV (2.2 +/- 0.3 x basal CBFV at 4.0 micromol/min) and in epicardial artery diameter (+ 15 +/- 6% diam). Left main infusions (8 micromol/min) caused a stepwise increase in CBFV and in the endocardial-to-epicardial flow ratio without affecting systemic hemodynamics. Brief infusion of NO (2 min) did not significantly reduce acetylcholine-mediated endothelial NO release. Therefore, despite rapid metabolism, direct intra-arterial infusion of NO can be given at a rate sufficient to overwhelm metabolic elimination, providing direct evidence that NO is a potent in vivo coronary vasodilator. Moreover, the enhanced subendocardial vasodilator response to direct NO infusion suggests increased regional sensitivity to NO.
J W Chambers; G S Voss; J R Snider; S M Meyer; J L Cartland; R F Wilson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-12-16     Completed Date:  1996-12-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1584-93     Citation Subset:  IM    
Department of Medicine, University of Minnesota, Minneapolis 55455, USA.
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MeSH Terms
Chemiluminescent Measurements
Coronary Circulation / drug effects*
Dose-Response Relationship, Drug
Endothelium, Vascular / physiology
Hemodynamics / drug effects
Infusions, Intravenous
Nitric Oxide / pharmacology*
Osmolar Concentration
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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