| Direct in vivo effects of nitric oxide on the coronary circulation. | |
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MedLine Citation:
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PMID: 8897955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the direct in vivo effects of nitric oxide (NO) on the coronary circulation, we infused NO-saturated saline (1.0 +/- 0.1 mmol/l) into the coronary arteries of anesthetized dogs and measured changes in coronary blood flow velocity (CBFV) with a Doppler catheter, changes in coronary artery size with quantitative angiography, and transmural myocardial perfusion with radioactive microspheres. Boluses of NO (1-8 micromol) caused a stepwise increase in CBFV (3.1 +/- 0.3 x basal CBFV at 8 micromol) similar to that caused by adenosine (2.6 +/- 0.3 x basal CBFV, maximal dose). Continuous subselective infusions (0.1, 1.0, and 4.0 micromol/min) caused dose-dependent increases in CBFV (2.2 +/- 0.3 x basal CBFV at 4.0 micromol/min) and in epicardial artery diameter (+ 15 +/- 6% diam). Left main infusions (8 micromol/min) caused a stepwise increase in CBFV and in the endocardial-to-epicardial flow ratio without affecting systemic hemodynamics. Brief infusion of NO (2 min) did not significantly reduce acetylcholine-mediated endothelial NO release. Therefore, despite rapid metabolism, direct intra-arterial infusion of NO can be given at a rate sufficient to overwhelm metabolic elimination, providing direct evidence that NO is a potent in vivo coronary vasodilator. Moreover, the enhanced subendocardial vasodilator response to direct NO infusion suggests increased regional sensitivity to NO. |
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Authors:
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J W Chambers; G S Voss; J R Snider; S M Meyer; J L Cartland; R F Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 271 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-12-16 Completed Date: 1996-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1584-93 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Minnesota, Minneapolis 55455, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemiluminescent Measurements Coronary Circulation / drug effects* Dogs Dose-Response Relationship, Drug Endothelium, Vascular / physiology Female Hemodynamics / drug effects Infusions, Intravenous Male Nitric Oxide / pharmacology* Osmolar Concentration Pericardium Vasodilation |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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