Document Detail

Direct fetal glucocorticoid treatment alters postnatal adaptation in premature newborn baboons.
MedLine Citation:
PMID:  9575985     Owner:  NLM     Status:  MEDLINE    
Abnormalities of premature newborn adaptation after preterm birth result in significant perinatal mortality and morbidity. We assessed the effects of short-term (24 h) fetal betamethasone exposure on preterm newborn baboon pulmonary and cardiovascular regulation and renal sodium handling during the first 24 h after birth. Male fetal baboons (Papio) (124-day gestation, term 185 days) received ultrasound-guided intramuscular injections of saline (n = 5) or betamethasone (0.5 mg/kg; n = 5). Fetuses were cesarean delivered 24 h later, treated with 100 mg/kg surfactant, and ventilated by adjusting peak inspiratory pressures to maintain PCO2 values of 35-50 mmHg for 24 h. Betamethasone- vs. saline-treated mean +/- SE newborn body weights (0.45 +/- 0.02 vs. 0.41 +/- 0.01 kg) were similar. Although prenatal betamethasone did not affect postnatal lung function (PCO2, arterial/alveolar O2 gradient, or dynamic compliance), plasma hormone (cortisol or thyroxine), or catecholamine levels, mean arterial pressure (25 +/- 1 vs. 32 +/- 1 mmHg), plasma sodium concentration (132 +/- 2 vs. 138 +/- 1 meq/l), glomerular filtration rate (0.07 +/- 0.02 vs. 0.16 +/- 0.02, and renal total sodium reabsorption (1.5 +/- 0.5 vs. 16.0 +/- 3.0 mu values were significantly lower in saline-treated than in betamethasone-treated newborns at 24 h. We conclude that despite the fact that there are no pulmonary and endocrine effects, antenatal glucocorticoid exposure alters premature newborn baboon vascular and renal glomerular function and improves sodium reabsorption after preterm delivery.
M G Ervin; S R Seidner; M M Leland; M Ikegami; A H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  274     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-02     Completed Date:  1998-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1169-76     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of California, Los Angeles School of Medicine, Harbor-UCLA Medical Center, Torrance 90502, USA.
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MeSH Terms
Adaptation, Physiological*
Animals, Newborn / physiology*
Betamethasone / pharmacology*
Blood Pressure / drug effects
Catecholamines / blood
Electrolytes / blood
Endocrine Glands / drug effects,  physiology
Gestational Age
Glucocorticoids / pharmacology*
Kidney / drug effects,  physiology
Lung / drug effects,  physiology
Prenatal Exposure Delayed Effects*
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Electrolytes; 0/Glucocorticoids; 378-44-9/Betamethasone

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