Document Detail

Direct excitatory effects of neuropeptide Y (NPY) on rat hippocampal neurones in vitro.
MedLine Citation:
PMID:  3594219     Owner:  NLM     Status:  MEDLINE    
Intracellular recordings from granule cells of the rat dentate gyrus show neuropeptide Y (NPY) applied by pressure ejection from pipettes containing 1.2-12 microM by pressures of less than 200 kPa for 1-5 s in duration to consistently evoke membrane depolarisations accompanied by a reduction in membrane resistance. The depolarisations were accompanied by an increase in excitability. Since the depolarisations evoked by NPY were not attenuated by either tetrodotoxin or kynurenic acid a direct excitatory action of NPY is postulated.
P A Brooks; J S Kelly; J M Allen; D A Smith; T W Stone
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  408     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-30     Completed Date:  1987-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  295-8     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Hippocampus / drug effects*,  physiology
Kynurenic Acid / pharmacology
Membrane Potentials / drug effects
Neuropeptide Y / pharmacology*
Rats, Inbred Strains
Reaction Time / drug effects
Tetrodotoxin / pharmacology
Reg. No./Substance:
0/Neuropeptide Y; 4368-28-9/Tetrodotoxin; 492-27-3/Kynurenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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