Document Detail


Direct evidence for uptake of intact liposomes encapsulating silver sulfadiazine by cultured human keratinocytes based on combined transmission electron microscopy and X-ray microanalysis.
MedLine Citation:
PMID:  9056023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cultured human keratinocytes were exposed to liposomally encapsulated silver sulfadiazine, free silver sulfadiazine, silver sulfadiazine cream, and a corresponding vehicle for 5 min to 24 h. Phagocytosis of intact liposomes by keratinocytes was demonstrated in vitro by combined X-ray microanalysis and electron microscopy. Silver as an active part of the antimicrobial served as an electron-dense marker.
Authors:
M Schaller; R Wurm; H C Korting
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  41     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-02     Completed Date:  1997-06-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Ludwig Maximilians University, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents, Local / administration & dosage,  pharmacokinetics*
Capsules
Cells, Cultured
Drug Carriers
Electron Probe Microanalysis
Humans
Keratinocytes / metabolism*,  ultrastructure
Liposomes
Microscopy, Electron
Ointments
Phagocytosis
Silver Sulfadiazine / administration & dosage,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Capsules; 0/Drug Carriers; 0/Liposomes; 0/Ointments; 22199-08-2/Silver Sulfadiazine
Comments/Corrections

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