| Direct evidence that inflammatory multinucleate giant cells form by fusion. | |
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MedLine Citation:
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PMID: 7097396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multinucleate giant cells (MGC) are believed to be formed by fusion of macrophages. In a chimaeric mouse composed of two histoincompatible strains each homozygous for one of the two isoenzymic forms of glucose-6-phosphate isomerase it was found that hybrid enzyme was produced in MGC-rich leucocytic exudates. This hybrid can only occur if nuclei of the two different strains reside within a common syncytial cytoplasm, demonstrating unequivocally that macrophage fusion occurred between cells of the two strains. Since the two strains were histoincompatible it appears that no strain specific recognition is necessary for fusion to occur. |
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Authors:
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A R Murch; M D Grounds; C A Marshall; J M Papadimitriou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pathology Volume: 137 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-09-10 Completed Date: 1982-09-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 177-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Fusion Chimera Electrophoresis, Starch Gel Inflammation / pathology* Isoenzymes / analysis Macrophages / pathology* Mice Mice, Inbred BALB C Mice, Inbred C57BL |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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