Document Detail


Direct evidence that coronary perfusion affects diastolic myocardial mechanical properties in canine heart.
MedLine Citation:
PMID:  8490939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The effect of coronary perfusion on left ventricular chamber distensibility is only indirect evidence that perfusion alters the mechanical properties of the myocardium. The aim of this study was to demonstrate explicitly the effects of coronary perfusion on these mechanical properties. METHODS: The effects of different levels of coronary perfusion were studied both on in-plane stress-strain relations and on transverse stiffness in an isolated, perfused canine interventricular septal preparation. Additionally, to determine the vascular compartment responsible for the mechanical effects of perfusion on tissue properties, we examined the in-plane stress-strain responses and transverse stiffness after embolisation of the vasculature with 15 microns microspheres. RESULTS: The data show a clear dependence of tissue stress-strain properties on perfusion. The in-plane stress-strain relations were shifted to the left and transverse stiffness increased linearly as septal artery perfusion pressure increased. The dependence of both the in-plane stress-strain relations and transverse stiffness on perfusion was significantly decreased following embolisation. CONCLUSIONS: Myocardial tissue stiffness is directly related to perfusion. The linear relationship between transverse stiffness and perfusion makes it easier to assess the effects of perfusion on tissue stiffness than with in-plane stress-strain relations. Perfusion of capillaries and/or venules is largely responsible for these alterations in myocardial stiffness.
Authors:
J R Resar; R M Judd; H R Halperin; V P Chacko; R G Weiss; F C Yin
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  27     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-06-16     Completed Date:  1993-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  403-10     Citation Subset:  IM    
Affiliation:
Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21205.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / physiology
Dogs
Heart Septum / physiology*
Myocardial Reperfusion / adverse effects*
Myocardium
Pressure
Stress, Mechanical
Ventricular Function, Left / physiology*
Grant Support
ID/Acronym/Agency:
R01-HL33621/HL/NHLBI NIH HHS; R01-HL44092/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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