Document Detail


Direct evidence for systemic fibrinogenolysis in patients with acquired alpha 2-plasmin inhibitor deficiency.
MedLine Citation:
PMID:  8250008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine whether or not acquired alpha 2-plasmin inhibitor deficiency is associated with systemic fibrinogenolysis, we analyzed the fibrin and fibrinogen degradation products in eight patients with this condition in various disease states. The underlying disease was gastric cancer in three patients, metastatic prostatic cancer in two, acute promyelocytic leukemia in two, and abdominal aortic aneurysm in one patient. In all eight patients, the alpha 2-plasmin inhibitor level was reduced to less than 50% of normal, and plasmin-alpha 2-plasmin inhibitor complex levels were increased. Immunoblotting of serum using an antifibrinogen antibody detected a 250 kDa protein (corresponding to fragments X or DY) in all eight patients. Fragment Y and D monomer were detected in seven of the eight patients, indicating the occurrence of systemic fibrinogenolysis. However, they were not detected in one patient with metastatic prostatic cancer. To determine whether or not fibrinogen degradation was also occurring in the patient without fragment Y, we characterized the 250 kDa protein in all eight patients. The protein was found to be fragment X in the metastatic prostatic cancer patient without fragment Y, while it was fragment DY in the other seven patients. Thus, systemic fibrinogenolysis was present in all eight patients. In the two patients with metastatic prostatic cancer, the level of alpha 2-plasmin inhibitor gradually increased with the reduction of tumor size by treatment. Fragment X, fragment Y, and D monomer were not detected when the alpha 2-plasmin inhibitor level exceeded 60% of normal in both patients. In the other six patients fragment Y and D monomer also disappeared when the alpha 2-plasmin inhibitor level exceeded 60% of normal. These findings suggest that systemic fibrinogenolysis only occurs when the plasma levels of alpha 2-plasmin inhibitor falls below 60% of normal due to activation of the fibrinolytic system by various pathological conditions.
Authors:
K Okajima; I Kohno; G Soe; H Okabe; K Takatsuki; B R Binder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  45     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-01-06     Completed Date:  1994-01-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-24     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Kumamoto University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aortic Aneurysm, Abdominal / complications,  therapy
Chromatography, Affinity
Female
Fibrin Fibrinogen Degradation Products / metabolism
Fibrinogen / metabolism*
Humans
Immunoblotting
Leukemia, Promyelocytic, Acute / complications,  therapy
Male
Middle Aged
Prostatic Neoplasms / complications,  therapy
Stomach Neoplasms / complications,  therapy
alpha-2-Antiplasmin / deficiency*
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/alpha-2-Antiplasmin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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