| Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure. | |
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MedLine Citation:
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PMID: 19327525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Direct application of low-energy unfocused shock waves induces angiogenesis in ischemic soft tissue. The potential effects of epicardial shock wave therapy applied in direct contact to ischemic myocardium are uncertain. METHODS: For induction of ischemic heart failure in a rodent model, a left anterior descending artery ligation was performed in adult Sprague-Dawley rats. After 4 weeks, reoperation with (treatment group, n = 60) or without (control group, n = 60) epicardial shock wave therapy was performed. Low-energy shock waves were applied in direct contact with the infarcted myocardium (300 impulses at 0.38 mJ/m(2)). Additionally, healthy animals (n = 30) with normal myocardium were studied. Angiogenesis, ventricular function upregulation of growth factors, and brain natriuretic peptide levels were analyzed. RESULTS: Histologic analysis revealed significant angiogenesis 6 weeks (treatment group: 8.2 +/- 3.7 vs control group: 2.9 +/- 1.9 vessels per field, P = .016) and 14 weeks (treatment group: 7.1 +/- 3.1 vs control group: 3.2 +/- 1.8 vessels per field, P = .011) after shock wave treatment. In the treatment group ventricular function improved throughout the follow-up period (6 weeks: 37.4% +/- 9% [P < .001] and 14 weeks: 39.5% +/- 9% [P < .001]). No improvement of ventricular function was observed in the control group (6 weeks: 28.6% +/- 5% and 14 weeks: 21.4% +/- 5%). Rat brain natriuretic peptide 45 levels were lower in the treatment group compared with those in the control group 6 and 14 weeks after treatment. Vascular endothelial growth factor, Fms-related tyrosine kinase 1, and placental growth factor levels were upregulated after 24 and 48 hours and 7 days in the treatment group. No effects on healthy myocardium were observed. CONCLUSION: Direct epicardial low-energy shock wave therapy induces angiogenesis and improves ventricular function in a rodent model of ischemic heart failure. |
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Authors:
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Daniel Zimpfer; Seyedhossein Aharinejad; Johannes Holfeld; Anita Thomas; Julia Dumfarth; Raphael Rosenhek; Martin Czerny; Wolfgang Schaden; Mathias Gmeiner; Ernst Wolner; Michael Grimm |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 137 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 963-70 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiothoracic Surgery, Medical University of Vienna, Vienna, Austria. daniel.zimpfer@meduniwien.ac.at |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Heart Failure / etiology, therapy* Myocardial Infarction / complications Myocardial Ischemia / etiology, therapy* Neovascularization, Physiologic / physiology* Pericardium Rats Rats, Sprague-Dawley Ultrasonic Therapy* Ultrasonics Ventricular Function, Left / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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