Document Detail

Direct electrical stimulation of Heschl's gyrus for tinnitus treatment.
MedLine Citation:
PMID:  18094653     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES/HYPOTHESIS: The purpose of the study was to determine the effect of electrical stimulation of the auditory cortex in patients with tinnitus. STUDY DESIGN: Nonrandomized clinical trial. METHODS: Two patients with debilitating tinnitus refractory to conventional therapies were treated. Patients were evaluated with validated questionnaires and psychoacoustic measures to determine the frequency and pitch of their tinnitus. Tones at these frequencies were then presented to the first patient (RP) under magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) to determine the tonotopic map for these frequencies in Heschl's gyrus. These tonotopic sites were targeted for implant with a quadripolar electrode. In the second patient (MV), only the fMRI tonotopic map was performed. These fMRI results detected an area of increased activity, which was selected as the site for the implanted bipolar electrode. RESULTS: Patient RP (bilateral tinnitus for 2 years) has experienced a sustained reduction to near elimination of tinnitus with intracerebral implanted electrodes, whereas patient MV (unilateral tinnitus for 7 years) had an unsustained reduction in her tinnitus. CONCLUSION: These findings suggest that the perception and annoyance of tinnitus may be modulated or reduced through electrical stimulation of the auditory cortex. These unsustained effects for patient MV may have been influenced by the longstanding nature of her tinnitus or by another reason as yet undetermined.
Michael D Seidman; Dirk De Ridder; Kost Elisevich; Susan M Bowyer; Ilaaf Darrat; Jason Dria; Brad Stach; Quan Jiang; Norman Tepley; James Ewing; Marlee Seidman; Jinsheng Zhang
Related Documents :
19678603 - Diagnosing and treating hair loss.
9039473 - Unilateral vestibular neuritis with otolithic signs and off-vertical axis rotation.
22150473 - Critically ill cancer patients in the intensive care unit: short-term outcome and 1-yea...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Laryngoscope     Volume:  118     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  491-500     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, Henry Ford Health System, Detroit, MI 48323, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Auditory Cortex*
Electric Stimulation Therapy / methods*
Magnetic Resonance Imaging
Middle Aged
Prostheses and Implants*
Tinnitus / diagnosis,  therapy*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of evolution on the eustachian tube.
Next Document:  Management of tracheobronchial stenoses with endoprostheses: experience with 103 patients and 11 mod...