| Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria. | |
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MedLine Citation:
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PMID: 2928649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Toxic shock syndrome is associated with reversible cardiomyopathy. The cardiac dysfunction may be mediated by toxic shock syndrome toxin 1 (TSST-1), an exotoxin generated by Staphylococcus aureus. However, the effects of purified TSST-1 on cardiac function are unknown. In a study of the toxin's effect on myocardial function, TSST-1 (200 ng/mL) was added to muscle baths containing isolated rabbit atria. TSST-1 caused time-dependent inhibition of developed force (systolic function) but did not alter resting force (an index of muscle stiffness or cardiac compliance). These data show that TSST-1 can directly inhibit myocardial function, but the significance of this effect in patients with toxic shock syndrome remains to be determined. |
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Authors:
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R D Olson; D L Stevens; M E Melish |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Reviews of infectious diseases Volume: 11 Suppl 1 ISSN: 0162-0886 ISO Abbreviation: Rev. Infect. Dis. Publication Date: 1989 Jan-Feb |
Date Detail:
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Created Date: 1989-04-27 Completed Date: 1989-04-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905878 Medline TA: Rev Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S313-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Washington School of Medicine, Seattle. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Toxins* Enterotoxins / toxicity* Heart / physiology* Heart Atria Myocardial Contraction* Organ Culture Techniques Rabbits Staphylococcus aureus* Superantigens* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Toxins; 0/Enterotoxins; 0/Superantigens; 0/enterotoxin F, Staphylococcal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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