Document Detail

Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria.
MedLine Citation:
PMID:  2928649     Owner:  NLM     Status:  MEDLINE    
Toxic shock syndrome is associated with reversible cardiomyopathy. The cardiac dysfunction may be mediated by toxic shock syndrome toxin 1 (TSST-1), an exotoxin generated by Staphylococcus aureus. However, the effects of purified TSST-1 on cardiac function are unknown. In a study of the toxin's effect on myocardial function, TSST-1 (200 ng/mL) was added to muscle baths containing isolated rabbit atria. TSST-1 caused time-dependent inhibition of developed force (systolic function) but did not alter resting force (an index of muscle stiffness or cardiac compliance). These data show that TSST-1 can directly inhibit myocardial function, but the significance of this effect in patients with toxic shock syndrome remains to be determined.
R D Olson; D L Stevens; M E Melish
Related Documents :
3177679 - Epicardial activation after unsuccessful defibrillation shocks in dogs.
17915299 - The role of transmural ventricular heterogeneities in cardiac vulnerability to electric...
19468019 - Intractable cardiogenic shock in stress cardiomyopathy with left ventricular outflow tr...
506939 - Hypovolemia and hypotension complicating management of acute cardiogenic pulmonary edema.
10612289 - Comparison of two-dimensional electrophoresis patterns of heat shock protein hsp27 spec...
12239499 - Cardiogenic shock complicating acute carbon monoxide poisoning despite neurologic and m...
17115889 - The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-r...
2502249 - First myocardial infarctions in asian and white men.
1377359 - Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  11 Suppl 1     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1989 Jan-Feb
Date Detail:
Created Date:  1989-04-27     Completed Date:  1989-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S313-5     Citation Subset:  IM    
Department of Medicine, University of Washington School of Medicine, Seattle.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bacterial Toxins*
Enterotoxins / toxicity*
Heart / physiology*
Heart Atria
Myocardial Contraction*
Organ Culture Techniques
Staphylococcus aureus*
Time Factors
Reg. No./Substance:
0/Bacterial Toxins; 0/Enterotoxins; 0/Superantigens; 0/enterotoxin F, Staphylococcal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characteristics of toxic shock syndrome toxin 1-induced lectin-like activity and inhibitor(s) in rab...
Next Document:  Risk factors for menstrual toxic shock syndrome: results of a multistate case-control study.