Document Detail


Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria.
MedLine Citation:
PMID:  2928649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toxic shock syndrome is associated with reversible cardiomyopathy. The cardiac dysfunction may be mediated by toxic shock syndrome toxin 1 (TSST-1), an exotoxin generated by Staphylococcus aureus. However, the effects of purified TSST-1 on cardiac function are unknown. In a study of the toxin's effect on myocardial function, TSST-1 (200 ng/mL) was added to muscle baths containing isolated rabbit atria. TSST-1 caused time-dependent inhibition of developed force (systolic function) but did not alter resting force (an index of muscle stiffness or cardiac compliance). These data show that TSST-1 can directly inhibit myocardial function, but the significance of this effect in patients with toxic shock syndrome remains to be determined.
Authors:
R D Olson; D L Stevens; M E Melish
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  11 Suppl 1     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1989 Jan-Feb
Date Detail:
Created Date:  1989-04-27     Completed Date:  1989-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S313-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Washington School of Medicine, Seattle.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Toxins*
Enterotoxins / toxicity*
Heart / physiology*
Heart Atria
Myocardial Contraction*
Organ Culture Techniques
Rabbits
Staphylococcus aureus*
Superantigens*
Time Factors
Chemical
Reg. No./Substance:
0/Bacterial Toxins; 0/Enterotoxins; 0/Superantigens; 0/enterotoxin F, Staphylococcal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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