Document Detail

Direct effects of phosphate on vascular cell function.
MedLine Citation:
PMID:  21406295     Owner:  NLM     Status:  MEDLINE    
Elevated serum phosphate has clinically been associated with vascular stiffness and cardiovascular mortality. Mechanistic studies over the past decade regarding local effects of phosphate on the vessel wall have provided insight into various pathways that culminate in vascular calcification. Smooth muscle cell phenotype change and apoptosis play prominent roles. The sodium-phosphate cotransporter PiT-1 is required for the osteochondrogenic differentiation of smooth muscle cells in vitro. Less is known about phosphate-driven valve interstitial cell calcification and elastin degradation. In this article, we review the current knowledge about phosphate-induced changes in the vascular wall.
Wei Ling Lau; Ashwini Pai; Sharon M Moe; Cecilia M Giachelli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Advances in chronic kidney disease     Volume:  18     ISSN:  1548-5609     ISO Abbreviation:  Adv Chronic Kidney Dis     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-16     Completed Date:  2011-07-11     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101209214     Medline TA:  Adv Chronic Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Calcinosis / genetics,  metabolism*,  physiopathology
Extracellular Matrix / metabolism
Gene Expression Regulation
Hyperphosphatemia / genetics,  metabolism*,  physiopathology
Muscle, Smooth, Vascular / metabolism,  physiopathology
Phosphates / metabolism*
Renal Insufficiency, Chronic / genetics,  metabolism,  physiopathology
Sodium-Phosphate Cotransporter Proteins, Type III / metabolism
Grant Support
K24 DK002775/DK/NIDDK NIH HHS; K24 DK002775-05/DK/NIDDK NIH HHS; R01 AR058005/AR/NIAMS NIH HHS; R01 HL062329/HL/NHLBI NIH HHS; R01 HL062329-12/HL/NHLBI NIH HHS; R01 HL081785/HL/NHLBI NIH HHS; R01 HL081785-01/HL/NHLBI NIH HHS; R01 HL081785-05/HL/NHLBI NIH HHS; R01 HL62329/HL/NHLBI NIH HHS; T32 DK007467/DK/NIDDK NIH HHS; T32 DK007467/DK/NIDDK NIH HHS; T32 DK007467-29/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Phosphates; 0/Sodium-Phosphate Cotransporter Proteins, Type III

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