| Direct effects of nutrients, acetylcholine, CCK, and insulin on ghrelin release from the isolated stomachs of rats. | |
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MedLine Citation:
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PMID: 19463754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ghrelin is a powerful orexigenic peptide predominantly secreted by the stomach. Blood concentration of ghrelin increases before meals and fall postprandial. Its regulation appears to be influenced by the type of macronutrient ingested, the vagus nerve stimulation and by other post-meal stimulated hormonal factors. However, the direct role of nutrients (amino acids or lipids), neuronal (vagal neurotransmitter acetylcholine) and satiety-inducing factor such as CCK are not known. To study this we applied amino acids, lipids, acetylcholine and CCK via vascular perfusion to the isolated stomachs and found that amino acids significantly reduced ghrelin release from the isolated stomach by approximately approximately 30% vs. the control while lipids (10% intralipid) had no affect. Acetylcholine (1 microM) increased ghrelin release from the stomach by approximately 37% whereas insulin (10nM) decreased it by approximately 30% vs. the control. Interestingly, CCK (100 nM) potently increased ghrelin release by approximately 200% vs. the control. Therefore it appears that ghrelin secretion from the stomach is under direct influence of amino acids, neurotransmitter acetylcholine and hormones such as insulin and CCK. |
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Authors:
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Yogendra B Shrestha; Kathie Wickwire; Silvia Q Giraudo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-02-12 |
Journal Detail:
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Title: Peptides Volume: 30 ISSN: 1873-5169 ISO Abbreviation: Peptides Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-09-01 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 1187-91 Citation Subset: IM |
Affiliation:
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Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology* Amino Acids / pharmacology* Animals Cholecystokinin / pharmacology* Gastric Mucosa / drug effects, secretion* Ghrelin / drug effects*, metabolism, secretion Insulin / pharmacology* Lipids / pharmacology* Male Rats Rats, Sprague-Dawley Stomach / drug effects, metabolism, surgery |
| Grant Support | |
ID/Acronym/Agency:
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NIDDK-DK 59836//PHS HHS; R01 DK059836-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Ghrelin; 0/Lipids; 11061-68-0/Insulin; 51-84-3/Acetylcholine; 9011-97-6/Cholecystokinin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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