| Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretion. | |
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MedLine Citation:
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PMID: 9579235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study evaluated the effect of corticotrophin-releasing hormone (CRH) on growth hormone releasing hormone (GHRH)-stimulated growth hormone (GH) release in man. DESIGN: Six healthy adult volunteers (age 20-35 years) were studied. On different occasions they each received an intravenous bolus of saline, CRH(1-41) (100 micrograms), adrenocorticotrophic hormone (ACTH) [Synacthen (500 ng/m2)] or hydrocortisone (50 mg), followed 30 minutes later by an intravenous bolus of either GHRH-(1-29)-NH2 (1.0 microgram/kg) or saline. MEASUREMENT: Serum GH concentrations were measured using an immunoradiometric assay, and cortisol concentrations were measured by commercial radioimmunoassay. TSH concentrations were measured using a solid phase immunoradiometric assay kit. RESULTS: Pretreatment with CRH(1-41) attenuated the GH response to GHRH [saline/GHRH-(1-29)-NH2 20.2 +/- 6.2 mU/l; CRH(1-41)/GHRH-(1-29)-NH2 10.9 +/- 2.8 mU/l (P = 0.01)]. This effect was not due to the rise in ACTH or cortisol induced by CRH(1-41), since pretreatment with either ACTH or hydrocortisone significantly augmented the GH response to GHRH-(1-29)-NH2 in the same subjects [ACTH/GHRH-(1-29)-NH2 30.3 +/- 8.8 mU/l (P = 0.01); hydrocortisone/GHRH-(1-29)-NH2 36.4 +/- 11.2 mU/l (P = 0.02)]. CONCLUSION: Our data suggest that the inhibitory effect of CRH(1-41) on GHRH-(1-29)-NH2-induced GH release is not a result of ACTH or cortisol release but reflects a direct action of CRH on GH secretion, possibly via stimulation of somatostatin release. The acute rise in GH following glucocorticoid administration could be explained in part by a rapid suppression of endogenous CRH. |
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Authors:
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J Raza; A F Massoud; P C Hindmarsh; I C Robinson; C G Brook |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical endocrinology Volume: 48 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-05-26 Completed Date: 1998-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 217-22 Citation Subset: IM |
Affiliation:
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London Centre for Paediatric Endocrinology and Metabolism, Middlesex Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood,
pharmacology Adult Analysis of Variance Area Under Curve Corticotropin-Releasing Hormone / diagnostic use* Growth Hormone / blood, secretion* Growth Hormone-Releasing Hormone / pharmacology* Humans Hydrocortisone / blood*, pharmacology Immunoradiometric Assay Male Peptide Fragments / pharmacology* Stimulation, Chemical Thyrotropin / blood |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone; 9015-71-8/Corticotropin-Releasing Hormone; 9034-39-3/Growth Hormone-Releasing Hormone; 90830-28-7/somatotropin releasing hormone (1-29) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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