Document Detail


Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretion.
MedLine Citation:
PMID:  9579235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study evaluated the effect of corticotrophin-releasing hormone (CRH) on growth hormone releasing hormone (GHRH)-stimulated growth hormone (GH) release in man. DESIGN: Six healthy adult volunteers (age 20-35 years) were studied. On different occasions they each received an intravenous bolus of saline, CRH(1-41) (100 micrograms), adrenocorticotrophic hormone (ACTH) [Synacthen (500 ng/m2)] or hydrocortisone (50 mg), followed 30 minutes later by an intravenous bolus of either GHRH-(1-29)-NH2 (1.0 microgram/kg) or saline. MEASUREMENT: Serum GH concentrations were measured using an immunoradiometric assay, and cortisol concentrations were measured by commercial radioimmunoassay. TSH concentrations were measured using a solid phase immunoradiometric assay kit. RESULTS: Pretreatment with CRH(1-41) attenuated the GH response to GHRH [saline/GHRH-(1-29)-NH2 20.2 +/- 6.2 mU/l; CRH(1-41)/GHRH-(1-29)-NH2 10.9 +/- 2.8 mU/l (P = 0.01)]. This effect was not due to the rise in ACTH or cortisol induced by CRH(1-41), since pretreatment with either ACTH or hydrocortisone significantly augmented the GH response to GHRH-(1-29)-NH2 in the same subjects [ACTH/GHRH-(1-29)-NH2 30.3 +/- 8.8 mU/l (P = 0.01); hydrocortisone/GHRH-(1-29)-NH2 36.4 +/- 11.2 mU/l (P = 0.02)]. CONCLUSION: Our data suggest that the inhibitory effect of CRH(1-41) on GHRH-(1-29)-NH2-induced GH release is not a result of ACTH or cortisol release but reflects a direct action of CRH on GH secretion, possibly via stimulation of somatostatin release. The acute rise in GH following glucocorticoid administration could be explained in part by a rapid suppression of endogenous CRH.
Authors:
J Raza; A F Massoud; P C Hindmarsh; I C Robinson; C G Brook
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical endocrinology     Volume:  48     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-26     Completed Date:  1998-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
Affiliation:
London Centre for Paediatric Endocrinology and Metabolism, Middlesex Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood,  pharmacology
Adult
Analysis of Variance
Area Under Curve
Corticotropin-Releasing Hormone / diagnostic use*
Growth Hormone / blood,  secretion*
Growth Hormone-Releasing Hormone / pharmacology*
Humans
Hydrocortisone / blood*,  pharmacology
Immunoradiometric Assay
Male
Peptide Fragments / pharmacology*
Stimulation, Chemical
Thyrotropin / blood
Chemical
Reg. No./Substance:
0/Peptide Fragments; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone; 9015-71-8/Corticotropin-Releasing Hormone; 9034-39-3/Growth Hormone-Releasing Hormone; 90830-28-7/somatotropin releasing hormone (1-29)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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