| Direct effect of halothane and isoflurane on the function of the sarcoplasmic reticulum in intact rabbit atria. | |
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MedLine Citation:
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PMID: 2321786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The negative inotropic effect of halothane and isoflurane on potentiated-state contractions of isolated rabbit atria in a normal Ca2+ (2.5 mM) medium was compared with the force depression in low Ca2+ media without an anesthetic. When this comparison was made in the presence of 1 microM ryanodine so that the force of contraction was dependent only upon transsarcolemmal Ca2+ influx with no Ca2+ contribution from the sarcoplasmic reticulum (SR), the force of contraction was depressed equally by 0.6% halothane in a normal Ca2+ medium and by a 1.5 mM Ca2+ medium without the anesthetic. Similarly, 1.0% halothane or 1.5% isoflurane and a 1.0 mM Ca2+ medium were equally depressant as were 2.4% isoflurane and a 0.5 mM Ca2+ medium. In the absence of ryanodine, where the atrial contractile activity is largely dependent on Ca2+ released from the SR, 0.6% halothane in the normal Ca2+ medium depressed contractile force by 32%, whereas the force was depressed by only 16% in the 1.5 mM Ca2+ medium without the anesthetic. Similar results were obtained when the effects of 1.0% halothane and of 1.0 mM Ca2+ were compared. In contrast, the force of contraction measured in the absence of ryanodine was not at all inhibited by 1.5% isoflurane and minimally (11%) inhibited by 2.4% isoflurane. Consequently, the force depression by isoflurane was less than that found in the low Ca2+ media.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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H Komai; B F Rusy |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Anesthesiology Volume: 72 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-02 Completed Date: 1990-05-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 694-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, University of Wisconsin, Madison 53792. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / pharmacology Culture Media Halothane / pharmacology* Heart / physiology* Heart Atria Isoflurane / pharmacology* Myocardial Contraction / drug effects Myocardium / ultrastructure Osmolar Concentration Rabbits Ryanodine / pharmacology Sarcoplasmic Reticulum / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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GM29527/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 151-67-7/Halothane; 15662-33-6/Ryanodine; 26675-46-7/Isoflurane; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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