Document Detail

Direct detection of the vasopressin precursor.
MedLine Citation:
PMID:  7363854     Owner:  NLM     Status:  MEDLINE    
Cysteine-rich proteins were isolated from the hypothalamo-neurohypophyseal tract of dogs by high performance molecular weight chromatography. Trypsin digestion of these proteins produced a low molecular weight (LMW) peptide which was identified, by chemical and immunological assays, as (Arg8) vasopressin. There appear to be two forms of the precursor protein, one which has vasopressin immunoreactivity, and one which does not. Trypsin digestion of this latter protein produces high as well as LMW immunoreactivity. This suggests that the non-immunoreactive protein may be the precursor to the immunoreactive protein.
K A Gruber; M Morris
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrine research communications     Volume:  7     ISSN:  0093-6391     ISO Abbreviation:  Endocr Res Commun     Publication Date:  1980  
Date Detail:
Created Date:  1980-06-25     Completed Date:  1980-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426337     Medline TA:  Endocr Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-59     Citation Subset:  IM    
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MeSH Terms
Arginine Vasopressin* / immunology
Chromatography, High Pressure Liquid
Cysteine / analysis
Hypothalamo-Hypophyseal System / analysis*
Molecular Weight
Peptide Fragments
Protein Precursors / immunology,  isolation & purification*
Reg. No./Substance:
0/Peptide Fragments; 0/Protein Precursors; 113-79-1/Arginine Vasopressin; 52-90-4/Cysteine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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