| Direct detection of paramagnetic species in adriamycin perfused rat hearts. | |
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MedLine Citation:
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PMID: 2837204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Direct detection of paramagnetic species in control and adriamycin-perfused rat hearts has been carried out. Depending on the flow rate of the perfusion solution (8,4,2 and 1 ml/min) different paramagnetic species were observed: Fe(III)(g = 2.12) at 4 ml/min; three types of oxygen centered radicals of which two in control hearts (g = 2.05 g = 2.038 g = g = 2.008) and the third one (g = 2.03 g = 2.005) in adriamycin perfused hearts, at 2 ml/min. The latter radical was the only one observed at perfusion rate of 1 ml/min both in control and adriamycin treated systems. A relationship between the intracellular enzymatic reductive activation of the anthracycline and the occurrence of ischemic conditions (4,2 and 1 ml/min) in myocardial tissues is proposed basing on the relative amounts of the paramagnetic species above mentioned. |
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Authors:
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L Costa; V Malatesta; F Morazzoni; R Scotti; E Monti; L Paracchini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 153 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-07-01 Completed Date: 1988-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 275-80 Citation Subset: IM |
Affiliation:
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Dipartimento di Chimica Inorganica e Metallorganica e Centro CNR, Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Doxorubicin / pharmacology* Electron Spin Resonance Spectroscopy Female Heart / drug effects* Perfusion Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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23214-92-8/Doxorubicin |
| Comments/Corrections | |
Comment In:
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Biochem Biophys Res Commun. 1990 May 31;169(1):30-8
[PMID:
2161659
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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