Document Detail


Direct detection of paramagnetic species in adriamycin perfused rat hearts.
MedLine Citation:
PMID:  2837204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Direct detection of paramagnetic species in control and adriamycin-perfused rat hearts has been carried out. Depending on the flow rate of the perfusion solution (8,4,2 and 1 ml/min) different paramagnetic species were observed: Fe(III)(g = 2.12) at 4 ml/min; three types of oxygen centered radicals of which two in control hearts (g = 2.05 g = 2.038 g = g = 2.008) and the third one (g = 2.03 g = 2.005) in adriamycin perfused hearts, at 2 ml/min. The latter radical was the only one observed at perfusion rate of 1 ml/min both in control and adriamycin treated systems. A relationship between the intracellular enzymatic reductive activation of the anthracycline and the occurrence of ischemic conditions (4,2 and 1 ml/min) in myocardial tissues is proposed basing on the relative amounts of the paramagnetic species above mentioned.
Authors:
L Costa; V Malatesta; F Morazzoni; R Scotti; E Monti; L Paracchini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  153     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-07-01     Completed Date:  1988-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
Affiliation:
Dipartimento di Chimica Inorganica e Metallorganica e Centro CNR, Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Doxorubicin / pharmacology*
Electron Spin Resonance Spectroscopy
Female
Heart / drug effects*
Perfusion
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
23214-92-8/Doxorubicin
Comments/Corrections
Comment In:
Biochem Biophys Res Commun. 1990 May 31;169(1):30-8   [PMID:  2161659 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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