| Direct detection of oxygen free radicals produced in the viscera of burned rats using electron paramagnetic resonance spectroscopy. | |
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MedLine Citation:
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PMID: 11904076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To detect superoxide anion (O(-)(2)) signals in the heart, liver, lung and kidney tissues after burns. METHODS: Twenty-four male rats were randomized into 4 groups. The rats of experimental groups were immersed in 100 degrees C water for 15 seconds and 25% third-degree burn was created. Thoracotomy or laparotomy was performed at 5, 10, 15, 20 and 30 minutes after burn, and specimens of the heart, lung, liver kidney were obtained for burned rats. The specimens were then preserved in liquid nitrogen for cryo-preservation and detected immediately using EPR. RESULTS: The signals of superoxide O radical appeared in the heart, lung, 1iver and kidney specimens 10-15 minutes after burn. CONCLUSIONS: There is a direct evidence of oxygen free radicals (OFRs) injury to viscera of burned rats between 10-15 minutes after burn. |
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Authors:
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Wei Lu; Yulin Chen; Zhaofan Xia |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association Volume: 5 ISSN: 1008-1275 ISO Abbreviation: Chin. J. Traumatol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-03-20 Completed Date: 2002-05-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100886162 Medline TA: Chin J Traumatol Country: China |
Other Details:
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Languages: eng Pagination: 118-20 Citation Subset: IM |
Affiliation:
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Burn Center, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / analysis Burns / metabolism*, physiopathology Disease Models, Animal Electron Spin Resonance Spectroscopy / methods* Free Radicals / analysis*, metabolism Kidney / metabolism Liver / metabolism Lung / metabolism Male Oxygen Random Allocation Rats Rats, Sprague-Dawley Sensitivity and Specificity Viscera / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Free Radicals; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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