Document Detail

Direct demonstration of iron in a term placenta in two cases of beta-thalassemia.
MedLine Citation:
PMID:  15054818     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to quantify iron in the placentas at the end of pregnancy in two patients suffering from beta-thalassemia and compare the data to that recorded from the placentas of healthy women. Iron was quantified in placental specimens taken after the delivery. The specimens were subjected to chemical treatments in order to remove extracellular iron and leave the intracellular iron intact. After coloration, each specimen was subjected to quantitative analysis of images in order to identify and quantify iron. Our results demonstrated that in beta-thalassemia there is an accumulation of iron in the outer basal cytoplasm of the epithelial cells of placental cotyledons.
M Artico; G Ballati; S Bosco; D Cantarelli; G Nagar; A Grosso; F M Tranquilli Leali; C Cavallotti
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  75     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-31     Completed Date:  2004-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-2     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Department of Pharmacology of Natural Molecules and General Physiology, University "La Sapienza," Rome, Italy.
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MeSH Terms
Iron / metabolism*
Placenta / metabolism*
Pregnancy Complications / metabolism*
Pregnancy Outcome
beta-Thalassemia / metabolism*
Reg. No./Substance:

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