Document Detail


Direct and cross-protective effects of heat adaptation in cultured cells.
MedLine Citation:
PMID:  12802414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The model of 6-day dosed heat adaptation was developed on cultured rat H9c2 cardiomyoblasts and mouse C2c12 myoblasts. Heat adaptation produced a direct protective effect and increased the resistance of cells to heat shock. The cross-protective effect of heat adaptation was manifested in an increase in the resistance to staurosporine-induced damage. Heat adaptation did not protect cells from oxidative damage. As differentiated from adaptation of the organism, heat adaptation produces direct and cross-protective effects that develop due to the action of environmental factors in the absence of neurohumoral agents. It should be emphasized that the cross-protective effect of heat adaptation in cultured cells is specific to a certain type of damage.
Authors:
E A Monastyrskaya; L V Andreeva; M R Duchen; E B Manukhina; I Yu Malyshev
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  135     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2004-05-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-9     Citation Subset:  IM    
Affiliation:
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
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MeSH Terms
Descriptor/Qualifier:
Acclimatization*
Animals
Cells, Cultured
Enzyme Inhibitors / metabolism
Hot Temperature*
Mice
Myoblasts / metabolism*
Myocytes, Cardiac / metabolism*
Oxidative Stress
Rats
Staurosporine / metabolism
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 62996-74-1/Staurosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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