| Direct, controlled synthesis of the nonimmunogenic, hydrophilic polymer, poly(N-(2-hydroxypropyl)methacrylamide) via RAFT in aqueous media. | |
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MedLine Citation:
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PMID: 16004419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) is a nonimmunogenic, neutral-hydrophilic polymer currently employed in the delivery of anticancer drugs. Herein, we report conditions that facilitate the direct, controlled RAFT polymerization of HPMA in aqueous media. We demonstrate that the use of 4-cyanopentanoic acid dithiobenzoate and 4,4'-azobis(4-cyanopentanoic acid) as the chain transfer agent (CTA) and initiating species, respectively, in the presence of an acetic acid buffer solution at 70 degrees C is a suitable condition leading to controlled polymerization. The "living" nature of these polymerizations is demonstrated via chain-extension of an HPMA macroCTA to yield the corresponding poly(HPMA-b-HPMA) "homopolymer". |
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Authors:
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Charles W Scales; Yulia A Vasilieva; Anthony J Convertine; Andrew B Lowe; Charles L McCormick |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Biomacromolecules Volume: 6 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2005 Jul-Aug |
Date Detail:
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Created Date: 2005-07-11 Completed Date: 2005-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 1846-50 Citation Subset: IM |
Affiliation:
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Department of Polymer Science, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Magnetic Resonance Spectroscopy Polymers / chemistry* Polymethacrylic Acids / chemistry* Scattering, Radiation Water / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Polymers; 0/Polymethacrylic Acids; 40704-75-4/Duxon; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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