Document Detail


Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention.
MedLine Citation:
PMID:  20382412     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The aim of the study was to evaluate and compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). MATERIALS AND METHODS: We modified a previously published rabbit model of arterial thrombosis prevention [1,2] to compare unfractionated heparin and two different doses of two low-molecular weight heparin fragments--nadroparin and enoxaparin. Thrombosis in the distal aorta was triggered by vessel wall injury and critical stenosis. Blood flow in the damaged arterial segment was monitored by a flow probe placed distal to the constrictor. The primary endpoints of the study were: (1) cumulative flow, (2) time to occlusion and (3) residual clot weight. Thirty six animals were split into 6 groups with six animals in each group. Control groups were given saline or heparin and four more groups were used to compare LMWH's at 2 different doses. RESULTS: In our study, all treatments were superior to the saline control group (alpha<or=0,01). Standard heparin was inferior (alpha<or=0,05) to both low molecular weight heparins for all primary endpoints (cumulative flow, time to occlusion and residual clot weight). There were no differences between the LMWH's except for cumulative flow at high doses. CONCLUSIONS: This study revealed no relevant differences between nadroparin and enoxaparin for the primary endpoints of our model. Clinical use of each drug remains a personal preference.
Authors:
Michal Vlasin; Martin Dvorak; Martina Dvorakova; Petr Rauser; Leona Lexmaulova; Zdenek Gregor
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-04-10
Journal Detail:
Title:  Thrombosis research     Volume:  126     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-60     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
University of Veterinary and Pharmaceutical Sciences Brno, and st. Ann's Faculty Hosital Brno, Czech Republic. vlasinm@vfu.cz
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries
Clinical Trials as Topic
Enoxaparin / therapeutic use*
Heparin / therapeutic use
Heparin, Low-Molecular-Weight / therapeutic use*
Male
Nadroparin / therapeutic use
Rabbits
Thrombosis / drug therapy,  prevention & control*
Chemical
Reg. No./Substance:
0/Enoxaparin; 0/Heparin, Low-Molecular-Weight; 0/Nadroparin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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