| Direct communication of homologous and heterologous endocrine islet cells in culture. | |
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MedLine Citation:
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PMID: 7035468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transfer of 6-carboxyfluorescein between islet cells in monolayer culture was observed by fluorescence microscopy, and the endocrine cells involved in this transfer were identified by immunohistochemistry and electron microscopy. The results show that carboxyfluorescein was directly exchanged between homologous B-cells and also between B- and A- or D-cells. Successive microinjections of the probe into different cells of the same cluster showed the existence of separate territories, each formed by 2-8 communicating cells. Intercellular communication was not observed after every dye microinjection, and communicating and noncommunicating islet cells were found to coexist within the same cluster. The data indicate that the exchange of exogenous cytoplasmic molecules occurs between different types of endocrine islet cells. However, within a single cluster, all islet cells are not metabolically coupled to one another, at a given time. |
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Authors:
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P Meda; E Kohen; C Kohen; A Rabinovitch; L Orci |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of cell biology Volume: 92 ISSN: 0021-9525 ISO Abbreviation: J. Cell Biol. Publication Date: 1982 Jan |
Date Detail:
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Created Date: 1982-04-12 Completed Date: 1982-04-12 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 0375356 Medline TA: J Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 221-6 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication* Cells, Cultured Fluoresceins / diagnostic use Islets of Langerhans / cytology, physiology*, ultrastructure Microscopy, Electron Rats |
| Chemical | |
Reg. No./Substance:
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0/Fluoresceins; 3301-79-9/6-carboxyfluorescein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Cell Biol ISSN: 0021-9525 ISSN: 1540-8140 Publisher: The Rockefeller University Press |
Article Information Download PDF  Print publication date: Day: 1 Month: 1 Year: 1982 Volume: 92 Issue: 1 First Page: 221 Last Page: 226 ID: 2112014 Publisher Id: 82120304 PubMed Id: 7035468 |
| Direct communication of homologous and heterologous endocrine islet cells in culture | |
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