| Direct analysis of microbial extracts containing metabolites of ethylenediamine-type antihistamines via high-performance liquid chromatography-thermospray mass spectrometry. | |
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MedLine Citation:
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PMID: 1971499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The utility of high-performance liquid chromatography-thermospray mass spectrometry (HPLC-TSMS) for the characterization of the ethylenediamine-type antihistamines, pyrilamine, methapyrilene, tripelennamine, and thenyldiamine, and their methylene chloride-extractable microbial metabolites from a biological matrix is demonstrated. Typically, the [M + H]+ ion was detected as the base peak in the TS mass spectra of these compounds. The ethylenediamine-type antihistamine metabolites were detected in an extract of a fungal culture grown in the presence of 5 mg of the antihistamine. A detection limit of 200 ng was observed for the HPLC-TSMS analysis of pyrilamine. |
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Authors:
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W A Korfmacher; T A Getek; E B Hansen; C E Cerniglia |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Analytical biochemistry Volume: 185 ISSN: 0003-2697 ISO Abbreviation: Anal. Biochem. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-06-27 Completed Date: 1990-06-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370535 Medline TA: Anal Biochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 136-42 Citation Subset: IM |
Affiliation:
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National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid*
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methods Evaluation Studies as Topic Histamine H1 Antagonists / analysis*, metabolism Mass Spectrometry* / methods Methapyrilene / analysis Molecular Structure Mucorales / analysis Pyridines / analysis Pyrilamine / analysis Tripelennamine / analysis |
| Chemical | |
Reg. No./Substance:
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0/Histamine H1 Antagonists; 0/Pyridines; 91-79-2/thenyldiamine; 91-80-5/Methapyrilene; 91-81-6/Tripelennamine; 91-84-9/Pyrilamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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