| Direct airway injury results in elevated levels of sulfidopeptide leukotrienes, detectable in airway secretions. | |
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MedLine Citation:
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PMID: 1771235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sulfidopeptide leukotrienes (LTC4/D4/E4) are suspected to be important lipid mediators in inflammatory responses in the lung. Previous investigations have provided evidence to support enhanced synthesis and secretion of these eicosanoids into bronchoalveolar lavage fluid in patients with Adult Respiratory Distress Syndrome (ARDS). We have prospectively examined the relationship between sulfidopeptide leukotriene levels in tracheal aspirates of 14 intubated and mechanically ventilated patients. When compared with the aspirate from one patient who required ventilation because of respiratory muscle weakness, the tracheal aspirates from eight ARDS patients had elevated leukotriene levels (range 2020-2052 pg/aspirate). However, the aspirates from four of the five patients with direct airway injury [inhalational burn (n = 3) and massive aspiration of gastric contents (n = 2)] contained significantly higher amounts of sulfidopeptide leukotrienes (range 10309-52244 pg/aspirate). Three of the five patients with direct airway injury did not develop ARDS. We conclude that simple aspiration of tracheal secretions can be used to monitor airway leukotriene biosynthesis in patients with lung injury and that elevated airway leukotriene levels may reflect airway epithelial damage, but may not predict the development of ARDS. |
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Authors:
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A Sala; R C Murphy; N F Voelkel |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Prostaglandins Volume: 42 ISSN: 0090-6980 ISO Abbreviation: Prostaglandins Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1992-02-25 Completed Date: 1992-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0320271 Medline TA: Prostaglandins Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bronchi / injuries*, metabolism Chromatography, High Pressure Liquid Humans Leukotrienes / metabolism* Middle Aged Pneumonia, Aspiration / physiopathology Prospective Studies Radioisotope Dilution Technique Respiratory Distress Syndrome, Adult / etiology, metabolism SRS-A / chemistry, metabolism Suction Trachea / injuries*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL14985/HL/NHLBI NIH HHS; HL34303/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leukotrienes; 0/SRS-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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