| Direct access to 4-carboxy-1,8-naphthyridines and related compounds through Pfitzinger-type chemistry. | |
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MedLine Citation:
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PMID: 18461999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The 4-carboxy-1,8-naphthyrid-2-yl moiety is a useful ligand component in that it promotes lower energy electronic absorption in its metal complexes and also provides a useful tether for anchoring the ligand to a semiconductor surface. The synthon [2-(pivaloylamino)pyrid-3-yl]oxoacetic acid ethyl ester can be easily obtained in two steps from 2-aminopyridine. The Pfitzinger-type condensation of this molecule with a 2-acetylazaaromatic species in ethanolic KOH, after acidification, directly provides bi- and tridentate ligands containing the 4-carboxy-1,8-naphthyrid-2-yl moiety. |
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Authors:
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Ruifa Zong; Hui Zhou; Randolph P Thummel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-05-08 |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 73 ISSN: 0022-3263 ISO Abbreviation: J. Org. Chem. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-02 Completed Date: 2008-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: United States |
Other Details:
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Languages: eng Pagination: 4334-7 Citation Subset: IM |
Affiliation:
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Department of Chemistry, 136 Fleming Building, University of Houston, Houston, TX 77204-5003, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Magnetic Resonance Spectroscopy Naphthyridines / chemistry* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| Chemical | |
Reg. No./Substance:
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0/Naphthyridines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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