Document Detail


Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography.
MedLine Citation:
PMID:  23624949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Our goal was to use positron emission tomography (PET) to analyze the movement of radiolabeled agents in tissue to enable direct measurement of drug delivery to the brain.
PROCEDURES: Various (11)C- and (18) F-labeled compounds were delivered directly to an agarose phantom or rat striatum. Concentration profiles were extracted for analysis and fitted to diffusion models.
RESULTS: Diffusion coefficients ranged from 0.075 ± 0.0026 mm(2)/min ([(18) F]fluoride ion, 18 Da) to 0.0016 ± 0.0018 mm(2)/min ([(18) F]NPB4-avidin, 68 kDa) and matched well with predictions based on molecular weight (R (2) = 0.965). The tortuosity of the brain extracellular space was estimated to be 1.56, with the tissue clearance halftime of each tracer in the brain varying from 19 to 41 min.
CONCLUSIONS: PET is an effective modality to directly quantify the movement of locally delivered drugs or drug carriers. This continuous, noninvasive assessment of delivery will aid the design of better drug delivery methods.
Authors:
Rachael W Sirianni; Ming-Qiang Zheng; W Mark Saltzman; Yiyun Huang; Richard E Carson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging     Volume:  15     ISSN:  1860-2002     ISO Abbreviation:  Mol Imaging Biol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-23     Completed Date:  2014-04-21     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101125610     Medline TA:  Mol Imaging Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  596-605     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Brain / radionuclide imaging*
Diffusion
Male
Molecular Weight
Neostriatum / radionuclide imaging
Positron-Emission Tomography / methods*
Radiopharmaceuticals / diagnostic use*,  pharmacokinetics
Rats
Rats, Sprague-Dawley
Sepharose
Time Factors
Tissue Distribution
Grant Support
ID/Acronym/Agency:
R01 CA149128/CA/NCI NIH HHS; T32 DA022975/DA/NIDA NIH HHS; UL1 RR024139/RR/NCRR NIH HHS; UL1 TR000142/TR/NCATS NIH HHS; UL1RR024139/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 9012-36-6/Sepharose
Comments/Corrections

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