| Direct numerical simulation of single leukocyte deformation in microchannel flow for disease diagnosis. | |
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MedLine Citation:
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PMID: 20703694 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To better understand the physical mechanism of leukocyte separation via microfluidics, a level set method was employed to analyze the coupled deformation-flow of individual leukocytes in microfluidic parabolic shear blood flow. The results show that: (1) Weber number and viscosity ratio have great effects on the deformation of single leukocyte, (2) difference between the deformation and motion behavior of different subtypes of leukocytes (i.e., granulocytes, lymphocytes, monocytes) was observed, and (3) the existence of a second leukocyte significantly changes the leukocyte deformation and motion. These results shed light on the understanding of the motion and deformation of leukocytes in microchannel flow and provide a theoretical foundation for separating lymphocytes via microfluidics. |
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Authors:
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Z Y Luo; F Xu; T J Lu; B F Bai |
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Publication Detail:
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Type: Journal Article Date: 2010-05-05 |
Journal Detail:
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Title: Journal of medical systems Volume: 35 ISSN: 0148-5598 ISO Abbreviation: J Med Syst Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806056 Medline TA: J Med Syst Country: United States |
Other Details:
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Languages: eng Pagination: 869-76 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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