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Direct Measurement of Phage phi29 Stiffness Provides Evidence of Internal Pressure.
MedLine Citation:
PMID:  22648860     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Using AFM nanoindentation experiments, DNA-full phi29 phage capsids are shown to be stiffer than when empty. The presence of counterions softens full viruses in a reversible manner, indicating that pressure originates from the confined DNA. A finite element analysis of the experiments provides an estimate of the pressure of ∼40 atm inside the capsid, which is similar to theoretical predictions.
Authors:
Mercedes Hernando-Pérez; Roberto Miranda; María Aznar; José L Carrascosa; Iwan A T Schaap; David Reguera; Pedro J de Pablo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-31
Journal Detail:
Title:  Small (Weinheim an der Bergstrasse, Germany)     Volume:  -     ISSN:  1613-6829     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235338     Medline TA:  Small     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Dpto. Física de la Materia Condensada, Universidad Autónoma de Madrid, 28049-Madrid, Spain.
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