Document Detail


Direct Measurement of Gastroesophageal Reflux Episodes in Patients With Squamous Cell Carcinoma by 24-h pH-Impedance Monitoring.
MedLine Citation:
PMID:  21931379     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES:Recent studies have consistently reported a significant association between gastric atrophy and esophageal squamous cell carcinomas (ESCCs). However, causative factors responsible for the linkage remain to be clarified. Multichannel intraluminal impedance monitoring in conjunction with a pH sensor (MII-pH) is a reliable technique to evaluate gastroesophageal reflux (GER) episodes, independent of the acidity. We investigated the potential roles of GER in the pathogenesis of ESCC with MII-pH.METHODS:From August 2008 to May 2010, 14 consecutive inpatients with superficial ESCCs (ESCC group) and 14 age- and sex-matched inpatients without any esophageal dysplastic lesions (non-ESCC group) were enrolled. Twenty-four hour portable MII-pH monitoring was performed under standard hospitalized conditions. The data of MII-pH were used to identify acid reflux (AR: pH drop below 4.0 during a reflux episode) and non-AR (NAR: pH drop above 4.0 during a reflux episode).RESULTS:The median intragastric pH of the ESCC group was 4.7 (2.3-6.4), implying hypochlorhydria in this patient group. The numbers of total reflux and NAR episodes in the ESCC group were significantly higher than those in the non-ESCC group (56 (43-87) vs. 35.5 (18-47), P=0.016 for total reflux and 46.5 (32-84) vs. 24.5 (8-37), P=0.012 for NAR), whereas the numbers of AR were similar in both groups. In addition, there was significance in the category of percentage time of bolus reflux episodes.CONCLUSIONS:Using MII-pH monitoring, we revealed the clinical significance of GER, especially NAR, in ESCCs. NAR may be a key factor in the link between gastric atrophy and ESCCs.Am J Gastroenterol advance online publication, 20 September 2011; doi:10.1038/ajg.2011.282.
Authors:
Kaname Uno; Katsunori Iijima; Waku Hatta; Tomoyuki Koike; Yasuhiko Abe; Naoki Asano; Gen Kusaka; Tooru Shimosegawa
Related Documents :
22085249 - Use of hyperbaric oxygen in traumatic brain injury: retrospective analysis of data of 2...
10783449 - Correction of recurrent dislocation of the mandible in elderly patients by the dautrey ...
22185749 - Mitomycin c in revision endoscopic dacryocystorhinostomy: a prospective randomized study.
22244409 - Magnetic mini-mover procedure for pectus excavatum iii: safety and efficacy in a food a...
25188619 - Successful use of intravenous dexmedetomidine for magnetic resonance imaging sedation i...
21654129 - Salutary effect of parathyroidectomy on neuropsychiatric symptoms in patients with prim...
2758189 - Severe traumatic brain lesions in sweden. part 2: impact of aggressive neurosurgical in...
2294259 - Review of an 8-year experience with modifications of endoscopic suspension of the bladd...
21316089 - Doppler ultrasound-guided percutaneous nephrolithotomy: a prospective randomized study.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-20
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  -     ISSN:  1572-0241     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hospital readmissions among patients with decompensated cirrhosis.
Next Document:  Combination of Allergic Factors Can Worsen Diarrheic Irritable Bowel Syndrome: Role of Barrier Defec...