Document Detail

The Direct Incorporation of Perfusion Defect Information to Define Ischemia and Infarction in the Finite Element Model of the Left Ventricle.
MedLine Citation:
PMID:  25367177     Owner:  NLM     Status:  Publisher    
This paper describes the process in which complex lesion geometries (specified by computer generated perfusion defects) are incorporated in the description of nonlinear FE mechanical models used for specifying the motion of the left ventricle (LV) in the 4D XCAT phantom to simulate gated cardiac image data. An image interrogation process was developed to define the elements in the LV mesh as ischemic or infarcted based upon the values of sampled intensity levels of the perfusion maps. For every element of the FE mesh, intensity values were determined for each of the interior integration points and the average element intensity levels were determined. The elements with average intensity values below a user-controlled threshold were defined as ischemic or infarcted depending upon the model being defined. For the infarction model cases, the thresholding and interrogation process were repeated in order to define a border zone (BZ) surrounding the infarction. This methodology was evaluated using perfusion maps created by the Perfusion CArdiac-Torso (PCAT) phantom an extension of the 4D XCAT phantom. The PCAT was used to create 3D perfusion maps representing 90% occlusions at 4 locations (left anterior descending segments 6 and 9, left circumflex segment 11, right coronary artery segment 1) in the coronary tree. The volumes and shapes of the defects defined in the FE mechanical models were compared with perfusion maps produced by the PCAT. The models were incorporated into the XCAT phantom. The mechanical models showed distinct changes due to the addition of regions of ischemia and infarction. The volumes of the ischemic/infarcted regions of the models were nearly identical to those volumes obtained from the images and were highly correlated (R2 = 0.99).
Alexander I Veress; George S K Fung; Taek-Soo Lee; Benjamin M W Tsui; Paul W Segars; Grant T Gullberg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-1
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  -     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-4     Completed Date:  -     Revised Date:  2014-11-5    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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