| Direct C-H arylation of electron-deficient heterocycles with arylboronic acids. | |
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MedLine Citation:
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PMID: 20812741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver(I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated heterocycles that would be more difficult to access with traditional methods. |
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Authors:
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Ian B Seiple; Shun Su; Rodrigo A Rodriguez; Ryan Gianatassio; Yuta Fujiwara; Adam L Sobel; Phil S Baran |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 132 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-23 Completed Date: 2010-12-30 Revised Date: 2013-05-28 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 13194-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Boronic Acids
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chemistry* Carbon / chemistry* Heterocyclic Compounds / chemistry* Hydrogen / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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GM-073949/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Boronic Acids; 0/Heterocyclic Compounds; 1333-74-0/Hydrogen; 7440-44-0/Carbon |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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