Document Detail


Direct 1270 nm Irradiation as an Alternative to Photosensitized Generation of Singlet Oxygen to Induce Cell Death.
MedLine Citation:
PMID:  22091977     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This article is a highlight of the paper by Anquez et al. in this issue of Photochemistry and Photobiology and describes the potential benefits of direct excitation of molecular oxygen to produce singlet oxygen rather than using a photosensitizer. Due to its simplicity, the direct excitation of molecular oxygen can potentially overcome problems associated with systemic administration of dyes, such as skin photosensitivity and the clearance of free sensitizer from the body. However, concerns associated with the technique include indiscriminate generation of extracellular and intracellular singlet oxygen, the difficulty of controlling necrotic vs apoptotic cell death, and the possible consequences of thermal effects.
Authors:
Michael R Detty
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-17
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  -     ISSN:  1751-1097     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Photochemistry and Photobiology © 2011 American Society for Photobiology.
Affiliation:
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY.
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