| Dipyridamole and postoperative ischemic deficits in aneurysmal subarachnoid hemorrhage. | |
| | |
MedLine Citation:
|
PMID: 3903069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent evidence has suggested that the delayed cerebral ischemic deficits that often follow surgery for aneurysmal subarachnoid hemorrhage (SAH) may be due to a proliferative vasculopathy. This vascular pathology may result from an interaction between the platelets and the vessel wall. A single-blind controlled trial of dipyridamole administration in 677 patients presenting with SAH (of whom 348 came to surgery) was undertaken to test the hypothesis that the modification of platelet behavior might reduce the incidence of ischemic deficits. Blind independent assessment of the outcome in the surgical group based on the Glasgow Outcome Scale and the specific neurological deficits revealed no significant differences between the control and treatment groups. |
| | |
Authors:
|
M D Shaw; P M Foy; M Conway; J D Pickard; P Maloney; J A Spillane; D W Chadwick |
Related Documents
:
|
16861829 - Aneurysmal subarachnoid hemorrhage in a patient with human immunodeficiency virus type ... 20483029 - Cerebrovascular reactivity evaluated by transcranial doppler sonography in patients aft... 2109049 - Hypermetabolism in the acute stage of hemorrhagic cerebrovascular disease. 10234999 - The effect and management of delayed vasospasm after aneurysmal subarachnoid hemorrhage. 18330519 - Endovascular treatment of tiny ruptured anterior communicating artery aneurysms. 20103319 - Utility of remote wireless pressure sensing for endovascular leak detection after endov... 19649379 - Continuous glucose monitoring system: dawn period calibration does not change accuracy ... 11875679 - Time-related decay of the benefits of biofeedback therapy. 23453419 - Timing of curative treatment for prostate cancer: a systematic review. |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of neurosurgery Volume: 63 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 1985 Nov |
Date Detail:
|
Created Date: 1985-12-05 Completed Date: 1985-12-05 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 699-703 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Platelets
/
drug effects Clinical Trials as Topic Dipyridamole / therapeutic use* Humans Intracranial Aneurysm / complications, surgery* Ischemic Attack, Transient / drug therapy*, etiology Placebos Random Allocation Subarachnoid Hemorrhage / complications, surgery* |
| Chemical | |
Reg. No./Substance:
|
0/Placebos; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of perioperative platelet inhibition on postcarotid endarterectomy mural thrombus formation. ...
Next Document: Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the Nationa...