Document Detail

Dipyridamole and postoperative ischemic deficits in aneurysmal subarachnoid hemorrhage.
MedLine Citation:
PMID:  3903069     Owner:  NLM     Status:  MEDLINE    
Recent evidence has suggested that the delayed cerebral ischemic deficits that often follow surgery for aneurysmal subarachnoid hemorrhage (SAH) may be due to a proliferative vasculopathy. This vascular pathology may result from an interaction between the platelets and the vessel wall. A single-blind controlled trial of dipyridamole administration in 677 patients presenting with SAH (of whom 348 came to surgery) was undertaken to test the hypothesis that the modification of platelet behavior might reduce the incidence of ischemic deficits. Blind independent assessment of the outcome in the surgical group based on the Glasgow Outcome Scale and the specific neurological deficits revealed no significant differences between the control and treatment groups.
M D Shaw; P M Foy; M Conway; J D Pickard; P Maloney; J A Spillane; D W Chadwick
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  63     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-05     Completed Date:  1985-12-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  699-703     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Platelets / drug effects
Clinical Trials as Topic
Dipyridamole / therapeutic use*
Intracranial Aneurysm / complications,  surgery*
Ischemic Attack, Transient / drug therapy*,  etiology
Random Allocation
Subarachnoid Hemorrhage / complications,  surgery*
Reg. No./Substance:
0/Placebos; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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