Document Detail


Dipole localization of P300 and normal aging.
MedLine Citation:
PMID:  11073089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
At present, our understanding of how normal aging affects in vivo brain function is rudimentary. Therefore, the aim of the present study was to investigate age effects on auditory P300 topography. A recently developed dipole source model for P300 distinguishes overlapping P300 subcomponents and enhances reliability as well as validity of the measurement. 67 healthy subjects were examined using the P300 dipole model in addition to the scalp data measurement. The results show that P300 subcomponents reflect functionally different processes concerning age changes of P300 activities. Temporo-parietal P300 is smaller in older subjects, whereas frontal P300 is not attenuated. Age affected both P300 subcomponents' latencies. Therefore, the functionally different alteration of P300 subcomponents might be the reason for P300 topography changes with the P300 maximum more frontally in older age.
Authors:
T Frodl; G Juckel; J Gallinat; R Bottlender; M Riedel; U Preuss; H J Möller; U Hegerl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain topography     Volume:  13     ISSN:  0896-0267     ISO Abbreviation:  Brain Topogr     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-09     Completed Date:  2001-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8903034     Medline TA:  Brain Topogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
Affiliation:
Dept. of Psychiatry, Ludwig-Maximilians-University, Munich, Germany. tfrodlba@psy.med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adult
Aging / physiology*
Cerebral Cortex / physiology*
Electroencephalography
Event-Related Potentials, P300 / physiology*
Evoked Potentials, Auditory / physiology
Female
Humans
Male
Middle Aged
Models, Neurological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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