Document Detail

Dipolar molecules as impellers achieving electric-field-stimulated release.
MedLine Citation:
PMID:  20078044     Owner:  NLM     Status:  MEDLINE    
Here we report the design of a new external electric field-controlled release system using functional dipolar molecules as nanoimpellers. The dipolar molecule 4-(3-cyanophenyl)butylene, which can reorient in response to external electric fields with different frequencies because of its strong inherent dipole moment, was synthesized and grafted onto the inner surfaces of mesopores. Under an alternating electric field, the swinging flexible molecular chains consequently push guest molecules out of the pore voids. This innovative approach to controlled release may provide important application opportunities in tumor treatment with a number of advantages in terms of local release with targetability, external remote control, and the nonelectrochemical nature of the process.
Yingchun Zhu; Huijuan Liu; Fang Li; Qichao Ruan; Hua Wang; Masahiro Fujiwara; Lianzhou Wang; G Q Max Lu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  132     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1450-1     Citation Subset:  IM    
Key Lab of Inorganic Coating Materials, Shanghai Institute of Ceramics, CASS, Shanghai 200050, China.
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MeSH Terms
Analgesics, Non-Narcotic / administration & dosage*
Butanes / chemical synthesis,  chemistry*
Drug Delivery Systems / instrumentation,  methods*
Electromagnetic Fields
Ibuprofen / administration & dosage*
Molecular Structure
Nitriles / chemical synthesis,  chemistry*
Silicon Dioxide / chemistry*
Reg. No./Substance:
0/4-(3-cyanophenyl)butylene; 0/Analgesics, Non-Narcotic; 0/Butanes; 0/Nitriles; 15687-27-1/Ibuprofen; 7631-86-9/Silicon Dioxide

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